Meiosis initiator protein is a protein that in humans is encoded by the MEIOSIN gene.
MEIOSIN is a germ cell-specific transcription factor that acts as a gatekeeper of meiotic initiation in mammals, directing the critical switch from mitotic to meiotic cell division. Expressed in response to retinoic acid signaling, MEIOSIN forms a functional complex with STRA8 to directly activate the transcription of essential meiotic genes. This regulatory mechanism governs the timely entry of both male and female germ cells into meiosis, underpinning the formation of haploid gametes necessary for sexual reproduction. Loss of MEIOSIN disrupts meiotic gene activation and leads to infertility due to failure of meiotic progression.[5][6][7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000237452 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000085601 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Ishiguro KI, Matsuura K, Tani N, Takeda N, Usuki S, Yamane M, et al. (February 2020). "MEIOSIN Directs the Switch from Mitosis to Meiosis in Mammalian Germ Cells". Developmental Cell. 52 (4): 429–445.e10. doi:10.1016/j.devcel.2020.01.010. PMID 32032549.
- ^ Oatley JM, Griswold MD (February 2020). "MEIOSIN: A New Watchman of Meiotic Initiation in Mammalian Germ Cells". Developmental Cell. 52 (4): 397–398. doi:10.1016/j.devcel.2020.02.002. PMC 8555863. PMID 32097650.
- ^ Ishiguro KI, Shimada R (June 2022). "MEIOSIN directs initiation of meiosis and subsequent meiotic prophase program during spermatogenesis". Genes & Genetic Systems. 97 (1) 21-00054: 27–39. doi:10.1266/ggs.21-00054. PMID 34955498.