MC3482

MC3482
Clinical data
Drug class	Sirtuin-5 (SIRT5) inhibitor
Identifiers
	IUPAC name (2S)-5-[[(5S)-6-anilino-6-oxo-5-(phenylmethoxycarbonylamino)hexyl]amino]-5-oxo-2-(phenylmethoxycarbonylamino)pentanoic acid;
CAS Number	2922280-86-0;
PubChem CID	134694957;
ChemSpider	71117562;
ChEMBL	ChEMBL5208157;
Chemical and physical data
Formula	C33H38N4O8
Molar mass	618.687 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1=CC=C(C=C1)COC(=O)N[C@@H](CCCCNC(=O)CC[C@@H](C(=O)O)NC(=O)OCC2=CC=CC=C2)C(=O)NC3=CC=CC=C3;
	InChI InChI=1S/C33H38N4O8/c38-29(20-19-28(31(40)41)37-33(43)45-23-25-14-6-2-7-15-25)34-21-11-10-18-27(30(39)35-26-16-8-3-9-17-26)36-32(42)44-22-24-12-4-1-5-13-24/h1-9,12-17,27-28H,10-11,18-23H2,(H,34,38)(H,35,39)(H,36,42)(H,37,43)(H,40,41)/t27-,28-/m0/s1; Key:LDCYHYVNYRUUOL-NSOVKSMOSA-N;

MC3482 is a drug which acts as a sirtuin-5 (SIRT5) inhibitor. It has antiinflammatory effects and is used for research into the function of the SIRT5 enzyme complex.^[1]^[2]^[3]

References

^ Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. (2015). "SIRT5 regulation of ammonia-induced autophagy and mitophagy". Autophagy. 11 (2): 253–270. doi:10.1080/15548627.2015.1009778. PMC 4502726. PMID 25700560.
^ Molinari F, Feraco A, Mirabilii S, Saladini S, Sansone L, Vernucci E, et al. (May 2021). "SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes". Cells. 10 (5): 1126. doi:10.3390/cells10051126. PMC 8148511. PMID 34066961.
^ Xia Q, Yu Y, Zhan G, Zhang X, Gao S, Han T, et al. (May 2024). "The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia‑induced Neuroinflammation Following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1". Journal of Neuroimmune Pharmacology. 19 (1) 17. doi:10.1007/s11481-024-10117-x. PMID 38717643.

[1] Polletta L, Vernucci E, Carnevale I, Arcangeli T, Rotili D, Palmerio S, et al. (2015). "SIRT5 regulation of ammonia-induced autophagy and mitophagy". Autophagy. 11 (2): 253–270. doi:10.1080/15548627.2015.1009778. PMC 4502726. PMID 25700560.

[2] Molinari F, Feraco A, Mirabilii S, Saladini S, Sansone L, Vernucci E, et al. (May 2021). "SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes". Cells. 10 (5): 1126. doi:10.3390/cells10051126. PMC 8148511. PMID 34066961.

[3] Xia Q, Yu Y, Zhan G, Zhang X, Gao S, Han T, et al. (May 2024). "The Sirtuin 5 Inhibitor MC3482 Ameliorates Microglia‑induced Neuroinflammation Following Ischaemic Stroke by Upregulating the Succinylation Level of Annexin-A1". Journal of Neuroimmune Pharmacology. 19 (1) 17. doi:10.1007/s11481-024-10117-x. PMID 38717643.

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