Lymphocyte expansion molecule

Lymphocyte expansion molecule (LEXM) was considered to be a protein discovered in 2015, allegedly involved in immune responses (in mice) to some cancers and viruses.[1][2] The original paper however has since been retracted upon recommendation of Imperial College's investigators due to concerns about duplication of data.[3][4]

The protein was considered responsible for an increased production of T cells in mice. The protein was believed to be a potential target for drug discovery.[5][6] Scientists at Imperial College planned a gene therapy based on this protein.[1]

References

  1. ^ a b Knapton S (16 April 2015). "Scientists find key to 'turbo-charging' immune system to kill all cancers". telegraph.co.uk. The Telegraph. Retrieved 8 September 2017.
  2. ^ Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, et al. (May 2015). "RETRACTED: T cell metabolism. The protein LEM promotes CD8⁺ T cell immunity through effects on mitochondrial respiration". Science. 348 (6238): 995–1001. doi:10.1126/science.aaa7516. hdl:10044/1/34339. PMID 25883318. (Retracted, see doi:10.1126/science.aal5242, PMID 27980177,  Retraction Watch)
  3. ^ Berg J (16 December 2016). "Retraction". Science. 354 (6318). American Association for the Advancement of Science: 1385. Bibcode:2016Sci...354.1385B. doi:10.1126/science.aal5242. PMID 27980177.
  4. ^ Chawla DS (15 December 2016). "High-profile Science paper retracted for misconduct". Retraction Watch.
  5. ^ "Previously Unknown Protein Boosts Immunity to Cancer and Viruses". Genetic Engineering & Biotechnology News. 2015.
  6. ^ Johnston I (17 April 2015). "Game-changing' new way to fight cancer discovered". The Independent.
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