L-817818

L-817818
Identifiers
	IUPAC name [(2S)-2-aminopropyl] (2S)-6-amino-2-[[2-(2-naphthalen-2-yl-1H-benzo[g]indol-3-yl)acetyl]amino]hexanoate;
CAS Number	217480-27-8;
PubChem CID	5311375;
IUPHAR/BPS	2016;
ChemSpider	4470868;
ChEBI	CHEBI:177199;
ChEMBL	ChEMBL252764;
Chemical and physical data
Formula	C33H36N4O3
Molar mass	536.676 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@@H](COC(=O)[C@H](CCCCN)NC(=O)CC1=C(NC2=C1C=CC3=CC=CC=C32)C4=CC5=CC=CC=C5C=C4)N;
	InChI InChI=1S/C33H36N4O3/c1-21(35)20-40-33(39)29(12-6-7-17-34)36-30(38)19-28-27-16-15-23-9-4-5-11-26(23)32(27)37-31(28)25-14-13-22-8-2-3-10-24(22)18-25/h2-5,8-11,13-16,18,21,29,37H,6-7,12,17,19-20,34-35H2,1H3,(H,36,38)/t21-,29-/m0/s1; Key:NFVRGDRCCNEGBS-LGGPFLRQSA-N;

L-817818 is a chemical compound which acts as an agonist at somatostatin receptor 5. It has neuroprotective effects in animal models and modulates insulin release.^[1]^[2]^[3]^[4]^[5]

References

^ Rohrer SP, Schaeffer JM (2000). "Identification and characterization of subtype selective somatostatin receptor agonists". Journal of Physiology, Paris. 94 (3–4): 211–215. doi:10.1016/s0928-4257(00)00215-1. PMID 11087999.
^ Kiagiadaki F, Savvaki M, Thermos K (January 2010). "Activation of somatostatin receptor (sst 5) protects the rat retina from AMPA-induced neurotoxicity". Neuropharmacology. 58 (1): 297–303. doi:10.1016/j.neuropharm.2009.06.028. PMID 19576912.
^ Li Q, Zhang Y, Wu N, Yin N, Sun XH, Wang Z (August 2019). "Activation of somatostatin receptor 5 suppresses T-type Ca²⁺ channels through NO/cGMP/PKG signaling pathway in rat retinal ganglion cells". Neuroscience Letters. 708 134337. doi:10.1016/j.neulet.2019.134337. PMID 31220522.
^ Li Y, Li X, Geng C, Guo Y, Wang C (September 2021). "Somatostatin receptor 5 is critical for protecting intestinal barrier function in vivo and in vitro". Molecular and Cellular Endocrinology. 535 111390. doi:10.1016/j.mce.2021.111390. PMID 34224803.
^ Zhang Y, Wu N, Li Q, Hu X, Wang L, Sun JG, et al. (March 2021). "Neuroprotective effect of the somatostatin receptor 5 agonist L-817,818 on retinal ganglion cells in experimental glaucoma". Experimental Eye Research. 204 108449. doi:10.1016/j.exer.2021.108449. PMID 33465395.