L-797591

L-797591
Identifiers
	IUPAC name (2R)-N-(6-amino-2,2,4-trimethylhexyl)-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide;
CAS Number	217480-24-5;
PubChem CID	9938757;
IUPHAR/BPS	2015;
ChemSpider	8114382;
Chemical and physical data
Formula	C38H49N5O2
Molar mass	607.843 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC(CCN)CC(C)(C)CNC(=O)[C@@H](CC1=CC=CC2=CC=CC=C21)NC(=O)N(CCC3=CC=CC=C3)CCC4=CC=CC=N4;
	InChI InChI=1S/C38H49N5O2/c1-29(19-22-39)27-38(2,3)28-41-36(44)35(26-32-16-11-15-31-14-7-8-18-34(31)32)42-37(45)43(24-20-30-12-5-4-6-13-30)25-21-33-17-9-10-23-40-33/h4-18,23,29,35H,19-22,24-28,39H2,1-3H3,(H,41,44)(H,42,45)/t29?,35-/m1/s1; Key:MZKKCMXXGCRPGX-LMZJGDDPSA-N;

L-797591 is a chemical compound which acts as an agonist at somatostatin receptor 1. It modulates insulin release and has potential applications in the treatment of diabetes, as well as being used for basic research into the function of the SSTR1 receptor.^[1]^[2]

References

^ Stark A, Mentlein R (October 2002). "Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells". Regulatory Peptides. 108 (2–3): 97–102. doi:10.1016/s0167-0115(02)00152-0. PMID 12220732.
^ Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, et al. (October 2024). "Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3". Proceedings of the National Academy of Sciences of the United States of America. 121 (41) e2400298121. doi:10.1073/pnas.2400298121. PMC 11474030. PMID 39361640.

[1] Stark A, Mentlein R (October 2002). "Somatostatin inhibits glucagon-like peptide-1-induced insulin secretion and proliferation of RINm5F insulinoma cells". Regulatory Peptides. 108 (2–3): 97–102. doi:10.1016/s0167-0115(02)00152-0. PMID 12220732.

[2] Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, et al. (October 2024). "Selective ligand recognition and activation of somatostatin receptors SSTR1 and SSTR3". Proceedings of the National Academy of Sciences of the United States of America. 121 (41) e2400298121. doi:10.1073/pnas.2400298121. PMC 11474030. PMID 39361640.

[1]

[2]