Lício Velloso

Lício Velloso
Born
Lício Augusto Velloso

(1963-06-12) June 12, 1963
Belo Horizonte, Minas Gerais, Brazil
CitizenshipBrazil
EducationState University of Campinas
OccupationsPhysician, Researcher
EmployerState University of Campinas
Notable workGlutamate decarboxilase as an autoantigen in type 1 diabetes mellitus (1994)
AwardsCapes Thesis Award (2006)

Lício Augusto Velloso (June 12, 1963) is a Brazilian physician and scientist who studies molecular and cellular mechanisms involved in the genesis of obesity and diabetes mellitus.[1][2][3][4] Since May 2014, he has been a full member of the Brazilian Academy of Sciences (ABC).[1][5] He is considered one of the leading obesity researchers in Brazil.[6][7][8]

Biography

Born in Belo Horizonte, capital of Minas Gerais, Velloso moved to Campinas, in the interior of the state of São Paulo, to study medicine at the State University of Campinas (Unicamp).[1][9] He graduated from university in 1986.[9] He specialized in surgery at the same institution in 1989.[1]

The following year, he moved to Uppsala, Sweden, to study for his doctorate. At Uppsala University, he obtained his doctorate with the thesis Glutamate decarboxylase as an autoantigen in type 1 diabetes mellitus.[2][10]

After obtaining his PhD from the Swedish university, he began a postdoctoral fellowship at Unicamp under the supervision of Professor Mario José Abdalla Saad, with a scholarship from National Council for Scientific and Technological Development (CNPq) between 1994 and 1997. During 1995, he conducted another postdoctoral research at the Joslin Diabetes Center at Harvard University under the supervision of Professor Ron Kahn.[11]

He is one of Brazil's most renowned researchers in medical research on obesity and is the Coordinator of the Cell Signaling Laboratory at Unicamp, where he and his team of scientists study the molecular and cellular mechanisms that lead to the onset of obesity and diabetes.[12][13] He is a professor at Unicamp, a member of the São Paulo State Academy of Sciences (Aciesp), and since 2014 has been a member of the Brazilian Academy of Sciences (ABC).[1][14][15] Among his achievements is the demonstration that eating diets rich in saturated fats causes damage to the hypothalamus—the region of the brain that controls hunger. Such damage results from the activation of an inflammatory response. The persistence of this inflammation can lead to the death of neurons, making the treatment of this disease even more difficult.[16][17] Advances in his research have enabled the development of methods to study the function of the hypothalamus in human patients, which has helped to draw parallels between the disease in experimental models and in humans.[18][19]

Prizes

Among the awards he has received are the Capes Thesis Award for Thesis Carl Peter von Dietrich in 2006, as advisor for the thesis "Co-Activator-1 of the Peroxisome Proliferator-Activated Receptor (PGC-1): a gene transcription co-activator involved in the control of insulin secretion and peripheral action" produced by Claudio Teodoro de Souza, at the time a doctoral student at Unicamp.[20][21]

Articles

  • "Definition of in situ hypothalamic inflammation as an important mechanism involved in the hypothalamic dysfunction in obesity". Endocrinology 146: 4192, 2005.
  • "Identification of TLR4 as a triggering mechanism for hypothalamic inflammation in obesity". J Neurosci 29: 359, 2009.
  • "Demonstration of molecular crosstalk between insulin and angiotensin II signaling pathways". PNAS 93: 12490, 1996.
  • "Demonstration of neuronal apoptosis in the hypothalamus of animal models of obesity". PLoS One 4: e5045, 2009..

References

  1. ^ a b c d e "Licio Augusto Velloso". Brazilian Academy of Sciences. Archived from the original on February 20, 2025. Retrieved September 15, 2025.
  2. ^ a b "Licio Velloso na Folha de São Paulo sobre o novo medicamento para obesidade, a semaglutida". CEPID OCRC (in Brazilian Portuguese). January 5, 2023. Archived from the original on June 26, 2025. Retrieved September 15, 2025.
  3. ^ "Licio Augusto Velloso". State University of Campinas. Retrieved September 15, 2025.{{cite web}}: CS1 maint: deprecated archival service (link)
  4. ^ Ferrari, Leon (May 3, 2024). "Alunos de Medicina estão aprendendo a cozinhar, e você deveria fazer o mesmo; entenda". Estadão (in Brazilian Portuguese). Retrieved September 16, 2025.{{cite web}}: CS1 maint: deprecated archival service (link)
  5. ^ Ziegler, Maria (September 2, 2024). "Estudo revela novo fator envolvido no controle do gasto calórico". Folha de S.Paulo (in Brazilian Portuguese). Archived from the original on September 6, 2025. Retrieved September 15, 2025.
  6. ^ "Lício Velloso". São Paulo Research Foundation (in Brazilian Portuguese). Archived from the original on September 23, 2025. Retrieved September 23, 2025.
  7. ^ "Globo Repórter mostra que carboidratos não são vilões da dieta". Globo Repórter (in Brazilian Portuguese). May 24, 2019. Archived from the original on September 25, 2022. Retrieved September 23, 2025.
  8. ^ "Ideia surgiu em 2008". Estadão (in Brazilian Portuguese). February 25, 2013. Retrieved September 23, 2025.{{cite web}}: CS1 maint: deprecated archival service (link)
  9. ^ a b "Prof. Dr. Licio Augusto Velloso (UNICAMP, Campinas, Brasil)". SBEM (in Brazilian Portuguese). Archived from the original on October 23, 2021. Retrieved September 15, 2025.
  10. ^ "Prof. Dr. Lício Augusto Velloso" (PDF). Federal University of Juiz de Fora. Archived (PDF) from the original on September 15, 2025. Retrieved September 15, 2025.
  11. ^ "Novos membros | 2013" (PDF). Brazilian Academy of Sciences. 2013. Archived (PDF) from the original on February 13, 2025. Retrieved September 16, 2025.
  12. ^ Delmondes, Camila (February 5, 2020). "Laboratório de Sinalização Celular seleciona alunos de pós-graduação para projetos na área de obesidade". University of Campinas School of Medical Sciences. Archived from the original on September 16, 2025. Retrieved September 16, 2025.
  13. ^ "Problema de peso". Ciência Hoje (in Brazilian Portuguese). 2013. Archived from the original on May 23, 2025. Retrieved September 16, 2025.
  14. ^ "Licio Augusto Velloso". Academia de Ciências do Estado de São Paulo. Archived from the original on September 25, 2023. Retrieved September 16, 2025.
  15. ^ Ferrari, Leon (June 7, 2025). "Por que é comum recuperar peso após emagrecer? Pequena estrutura do cérebro pode guardar a resposta". Estadão (in Brazilian Portuguese). Retrieved September 16, 2025.{{cite web}}: CS1 maint: deprecated archival service (link)
  16. ^ Muniz, Ricardo (May 8, 2025). "Inflamação no cérebro induzida por dieta rica em gordura atrai células imunes de todo o corpo". São Paulo Research Foundation (in Brazilian Portuguese). Archived from the original on August 4, 2025. Retrieved September 16, 2025.
  17. ^ Barra, Mário (August 28, 2010). "Inflamação no cérebro pode acarretar obesidade e diabetes tipo 2". G1 (in Brazilian Portuguese). Archived from the original on November 21, 2023. Retrieved September 16, 2025.
  18. ^ "Dieta rica em gorduras causa lesão que abre caminho para a obesidade". Hospital das Clínicas da Unicamp (in Brazilian Portuguese). March 17, 2009. Archived from the original on August 3, 2025. Retrieved September 16, 2025.
  19. ^ "Pesquisa da Unicamp traça 'roteiro' de mecanismo do cérebro para chegar à obesidade". G1 (in Brazilian Portuguese). November 28, 2017. Archived from the original on October 1, 2023. Retrieved September 16, 2025.
  20. ^ "Três melhores teses de doutorado de 2005 são premiadas". Coordenação de Aperfeicoamento de Pessoal de Nível Superior. November 7, 2006. Archived from the original on January 19, 2025. Retrieved September 16, 2025.
  21. ^ "FCM concorre, novamente, ao Grande Prêmio Capes de Teses". University of Campinas School of Medical Sciences. January 29, 2008. Archived from the original on March 31, 2024. Retrieved March 31, 2024.
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