Kathryn S Lilley

Kathryn S Lilley
Alma materUniversity of Sheffield
Scientific career
FieldsProteomics
InstitutionsUniversity of Cambridge

Kathryn S Lilley is a professor of biochemistry at the University of Cambridge,[1] director of the Cambridge Centre for Proteomics,[2] and an elected member of the European Molecular Biology Organization (EMBO).[3]

Lilley is a member of the Jesus College at the University of Cambridge, where she holds the position of Director of Studies in Natural Sciences (Biological Part II Biochemistry and Genetics and Biological Part III Biochemistry and Systems Biology).[4]

Career

Kathryn S Lilley received her BSc and PhD in biochemistry from the University of Sheffield. After leading a research laboratory at the University of Leicester for 11 years, she established the Cambridge Centre for Proteomics at the University of Cambridge in 2001.[5] In 2012, Lilley became Professor of Cell Dynamics in the Department of Biochemistry at the University of Cambridge and the Deputy Head of the Department of Biochemistry in 2023.

Professor Lilley is known for her research in the study of dynamic changes in the cellular proteome and transcriptome,[6][7][8][9] and the development of open-source software for the analysis and visualization of complex molecular data.[10][11] Lilley's research focuses on developing new technologies to study subcellular architecture, localization/abundance of proteins, and how these change under perturbations.[12] These technologies include Localisation of Organelle Proteins by Isotope Tagging (LOPIT), Localization of organelle proteins using data-independent acquisition (DIA-LOP), and orthogonal organic phase separation (OOPS).[13][14][15] These technologies are applied in the Lilley lab group to a large range of scenarios, from vaccine safety to protein stability in extremophiles.[16]

Awards

Her research activity has been recognized with the Wellcome Trust Investigator Award in 2015,[17] the Juan Pablo Albar Proteome Pioneer Award from the European Proteomics Association (EuPA) in 2017,[18] and the Award for Distinguished Achievement in Proteomic Sciences from the Human Proteome Organization (HuPO) in 2018.[19]

References

  1. ^ "Kathryn Lilley". Department of Biochemistry, University of Cambridge. 2012-05-02. Retrieved 2022-09-15.
  2. ^ "Cambridge Centre for Proteomics". Cambridge Centre for Proteomics, University of Cambridge. 2018-08-06. Retrieved 2022-09-15.
  3. ^ "Find people in the EMBO Communities". people.embo.org. Retrieved 2022-09-15.
  4. ^ "Kathryn Lilley | Jesus College in the University of Cambridge". www.jesus.cam.ac.uk. Retrieved 2026-02-10.
  5. ^ "Kathryn Lilley". Proteomics 2026. Retrieved 2026-02-10.
  6. ^ Christoforou, Andy; Mulvey, Claire M.; Breckels, Lisa M.; Geladaki, Aikaterini; Hurrell, Tracey; Hayward, Penelope C.; Naake, Thomas; Gatto, Laurent; Viner, Rosa; Arias, Alfonso Martinez; Lilley, Kathryn S. (2016-01-12). "A draft map of the mouse pluripotent stem cell spatial proteome". Nature Communications. 7 (1): 9992. Bibcode:2016NatCo...7.9992C. doi:10.1038/ncomms9992. ISSN 2041-1723. PMC 4729960. PMID 26754106.
  7. ^ Thul, Peter J.; Åkesson, Lovisa; Wiking, Mikaela; Mahdessian, Diana; Geladaki, Aikaterini; Ait Blal, Hammou; Alm, Tove; Asplund, Anna; Björk, Lars; Breckels, Lisa M.; Bäckström, Anna; Danielsson, Frida; Fagerberg, Linn; Fall, Jenny; Gatto, Laurent (2017-05-26). "A subcellular map of the human proteome". Science. 356 (6340) eaal3321. doi:10.1126/science.aal3321. ISSN 0036-8075. PMID 28495876. S2CID 10744558.
  8. ^ Queiroz, Rayner M. L.; Smith, Tom; Villanueva, Eneko; Marti-Solano, Maria; Monti, Mie; Pizzinga, Mariavittoria; Mirea, Dan-Mircea; Ramakrishna, Manasa; Harvey, Robert F.; Dezi, Veronica; Thomas, Gavin H.; Willis, Anne E.; Lilley, Kathryn S. (February 2019). "Comprehensive identification of RNA–protein interactions in any organism using orthogonal organic phase separation (OOPS)". Nature Biotechnology. 37 (2): 169–178. doi:10.1038/s41587-018-0001-2. ISSN 1087-0156. PMC 6591131. PMID 30607034.
  9. ^ "How mapping the human proteome reveals new insights into our bodies". the Guardian. 2014-06-19. Retrieved 2022-09-16.
  10. ^ Gatto, Laurent; Lilley, Kathryn S. (2012-01-15). "MSnbase-an R/Bioconductor package for isobaric tagged mass spectrometry data visualization, processing and quantitation". Bioinformatics. 28 (2): 288–289. doi:10.1093/bioinformatics/btr645. ISSN 1460-2059. PMID 22113085.
  11. ^ Geladaki, Aikaterini; Kočevar Britovšek, Nina; Breckels, Lisa M.; Smith, Tom S.; Vennard, Owen L.; Mulvey, Claire M.; Crook, Oliver M.; Gatto, Laurent; Lilley, Kathryn S. (2019-01-18). "Combining LOPIT with differential ultracentrifugation for high-resolution spatial proteomics". Nature Communications. 10 (1): 331. Bibcode:2019NatCo..10..331G. doi:10.1038/s41467-018-08191-w. ISSN 2041-1723. PMC 6338729. PMID 30659192.
  12. ^ "Kathryn Lilley". Proteomics 2026. Retrieved 2026-02-10.
  13. ^ "Human Proteome Organization (HUPO) - Localization of Organelle Proteins by Isotope Tagging (LOPIT): past, present and future". hupo.org. Retrieved 2026-02-10.
  14. ^ McCaskie, Kieran; Hutchings, Charlotte; Feret, Renata; Kim, Yong-In; Breckels, Lisa; Deery, Michael; Lilley, Kathryn (2025-09-01). "Localization of Organelle Proteins Using Data-Independent Acquisition (DIA-LOP)". Molecular & Cellular Proteomics. 24 (9) 101047. doi:10.1016/j.mcpro.2025.101047. ISSN 1535-9476. PMC 12455123. PMID 40783120.
  15. ^ Queiroz, Rayner M. L.; Smith, Tom; Villanueva, Eneko; Marti-Solano, Maria; Monti, Mie; Pizzinga, Mariavittoria; Mirea, Dan-Mircea; Ramakrishna, Manasa; Harvey, Robert F.; Dezi, Veronica; Thomas, Gavin H.; Willis, Anne E.; Lilley, Kathryn S. (February 2019). "Comprehensive identification of RNA-protein interactions in any organism using orthogonal organic phase separation (OOPS)". Nature Biotechnology. 37 (2): 169–178. doi:10.1038/s41587-018-0001-2. ISSN 1546-1696. PMC 6591131. PMID 30607034.
  16. ^ "Kathryn Lilley". Proteomics 2026. Retrieved 2026-02-10.
  17. ^ Grant, Rhys (2018-04-16). "Kathryn Lilley receives joint Wellcome Trust Investigator Award". www.bioc.cam.ac.uk. Retrieved 2022-09-15.
  18. ^ Administrator (2017-09-27). "Kathryn Lilley awarded the 2017 Juan Pablo Albar Proteome Pioneer Award". www.sysbiol.cam.ac.uk. Retrieved 2022-09-15.
  19. ^ "Professor Kathryn Lilley collects award". www.jesus.cam.ac.uk. Retrieved 2022-09-15.
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