Isotocyanozene

Isotocyanozene
Identifiers
  • 1-[2-(diethylamino)ethyl]-2-[(4-prop-2-yloxyphenyl)methyl]benzimidazole-5-carbonitrile
Chemical and physical data
FormulaC24H30N4O
Molar mass390.531 g·mol−1
3D model (JSmol)
  • CC(C)Oc1ccc(cc1)Cc1nc2cc(ccc2n1CCN(CC)CC)C#N
  • InChI=InChI=1S/C24H30N4O/c1-5-27(6-2)13-14-28-23-12-9-20(17-25)15-22(23)26-24(28)16-19-7-10-21(11-8-19)29-18(3)4/h7-12,15,18H,5-6,13-14,16H2,1-4H3
  • Key:PCHKHUKJPIKAGU-UHFFFAOYSA-N

Isotocyanozene (5-cyano-isotodesnitazene) is a benzimidazole opioid analogue of isotonitazene which has been sold as a designer drug. It was first prospectively observed in a toxicological sample in Scotland, United Kingdom in 2025, and was presumed to have opioid effects.[1] It has been identified by the drug checking service CanTEST, Australia in September 2025 as an expected 'opioid' sample, and then later as an expected 'benzodiazepine' sample.[2][3] Its in vitro biological activity is close to that of fentanyl.[4]

See also

References

  1. ^ McHenry RD, Dunlop LC, Hudson S, Walters M, Dear JW, Lowe DJ (July 2025). "Isotocyanozene: detection of the 5-cyano analog of isotonitazene in human biological samples". Clinical Toxicology. 63 (9). Philadelphia, Pa.: 691–692. doi:10.1080/15563650.2025.2528990. PMID 40625206.
  2. ^ "Community Notice 22nd of September 2025: Isotocyanozene found in 'opioid' capsule". CanTEST. Health and drug checking service, Canberra. September 2025.
  3. ^ "Isotocyanozene found in 'opioid' capsule". The Know. 2025-09-22. Retrieved 2025-09-23.
  4. ^ Curtis B, Lawes DJ, Persson M, Caldicott D, Green H, Norman C, et al. "Identification of isotocyanozene at an Australian drug checking service". ChemRxiv. 2026 (212). doi:10.26434/chemrxiv.15000033/v1.



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