Isobavachalcone
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| Formula | C20H20O4 |
| Molar mass | 324.376 g·mol−1 |
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Isobavachalcone is a natural product from the prenylated chalconoid family.[1][2][3]
It can be isolated from numerous medicinal plant species including Psoralea corylifolia, Fructus psoraleae, and Angelica keiskei.[2][3] It has antiiflammatory, antiviral and anti-cancer properties in vitro and plants containing isobavachalcone are used in Chinese herbal medicine for the treatment of osteoporosis and other aging-related diseases.[4][5][6][7]
See also
References
- ^ Wang M, Lin L, Lu JJ, Chen X (March 2021). "Pharmacological review of isobavachalcone, a naturally occurring chalcone". Pharmacological Research. 165 105483. doi:10.1016/j.phrs.2021.105483. PMID 33577976.
- ^ a b Zhou K, Yang S, Li SM (December 2021). "Naturally occurring prenylated chalcones from plants: structural diversity, distribution, activities and biosynthesis". Natural Product Reports. 38 (12): 2236–2260. doi:10.1039/d0np00083c. PMID 33972962.
- ^ a b Xing N, Meng X, Wang S (August 2022). "Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms". Phytotherapy Research. 36 (8): 3120–3142. doi:10.1002/ptr.7520. PMID 35684981.
- ^ Kuete V, Sandjo LP (July 2012). "Isobavachalcone: an overview". Chinese Journal of Integrative Medicine. 18 (7): 543–547. doi:10.1007/s11655-012-1142-7. PMID 22772918.
- ^ Zhou YT, Zhu L, Yuan Y, Ling S, Xu JW (2020). "Effects and Mechanisms of Five Psoralea Prenylflavonoids on Aging-Related Diseases". Oxidative Medicine and Cellular Longevity. 2020 2128513. doi:10.1155/2020/2128513. PMC 7320294. PMID 32655760.
- ^ Solnier J, Fladerer JP (2021). "Flavonoids: A complementary approach to conventional therapy of COVID-19?". Phytochemistry Reviews. 20 (4): 773–795. Bibcode:2021PChRv..20..773S. doi:10.1007/s11101-020-09720-6. PMC 7500502. PMID 32982616.
- ^ Liu X, Xu X, Li J, Shi L, Zeng Y, Tang S, et al. (August 2023). "Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells". Bioscience, Biotechnology, and Biochemistry. 87 (9): 960–971. doi:10.1093/bbb/zbad075. PMID 37291698.
Further reading
- Dong WH, Chu QQ, Liu SQ, Deng DT, Xu Q (September 2020). "Isobavachalcone ameliorates diabetic nephropathy in rats by inhibiting the NF-κB pathway". Journal of Food Biochemistry. 44 (9) e13405. doi:10.1111/jfbc.13405. PMID 32710574.
- Liu X, Xu X, Li J, Shi L, Zeng Y, Tang S, et al. (August 2023). "Isobavachalcone inhibits RANKL-induced osteoclastogenesis via miR-193-3p/NF-κB/NFATc1 signaling pathway in BMMs cells". Bioscience, Biotechnology, and Biochemistry. 87 (9): 960–971. doi:10.1093/bbb/zbad075. PMID 37291698.
- Ren YL, Lei JT, Zhang TR, Lu P, Cui DD, Yang B, et al. (April 2024). "Isobavachalcone, a natural sirtuin 2 inhibitor, exhibits anti-triple-negative breast cancer efficacy in vitro and in vivo". Phytotherapy Research. 38 (4): 1815–1829. doi:10.1002/ptr.8143. PMID 38349045.
- Kour D, Khajuria P, Sharma K, Sharma A, Sharma A, Ali SM, et al. (2025). "Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice". Frontiers in Pharmacology. 16 1525364. doi:10.3389/fphar.2025.1525364. PMC 11965660. PMID 40183098.
- Xie F, Zhu C, Sun L, Lin Q, Fang P, Li A, et al. (September 2025). "Isobavachalcone inhibits α-synuclein fibrillogenesis and its Parkinson's disease variants, disassembles the mature fibrils and alleviates cellular toxicity". International Journal of Biological Macromolecules. 322 (Pt 1) 146541. doi:10.1016/j.ijbiomac.2025.146541. PMID 40763859.
- Lee EJ, Shaikh S, Ahmad K, Lee SH, Choi JM, Lee YH, et al. (December 2025). "Isobavachalcone reduces blood glucose and promotes muscle development via dipeptidyl peptidase-4 inhibition". International Journal of Biological Macromolecules. 339 (Pt 1) 149858. doi:10.1016/j.ijbiomac.2025.149858. PMID 41443458.