Imidazoleacetate 4-monooxygenase
| imidazoleacetate 4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.5 | ||||||||
| CAS no. | 9029-65-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an imidazoleacetate 4-monooxygenase (EC 1.14.13.5) is an enzyme that catalyzes the chemical reaction
- 4-imidazoleacetate + NADH + H+ + O2 5-hydroxy-4-imidazoleacetate + NAD+ + H2O
The 4 substrates of this enzyme are 4-imidazoleacetate, NADH, H+, and O2, whereas its 3 products are 5-hydroxy-4-imidazoleacetate, NAD+, and H2O.
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 4-imidazoleacetate,NADH:oxygen oxidoreductase (5-hydroxylating). Other names in common use include imidazoleacetic hydroxylase, imidazoleacetate hydroxylase, and imidazoleacetic monooxygenase. This enzyme participates in histidine metabolism. It employs one cofactor, FAD.
References
- Maki Y, Yamamoto S, Nozaki M, Hayaishi O (1969). "Studies on monooxygenases. II. Crystallization and some properties of imidazole acetate monooxygenase". J. Biol. Chem. 244 (11): 2942–50. doi:10.1016/S0021-9258(18)91715-1. PMID 5772468.