Hydrogen therapy

Hydrogen therapy is the use of molecular hydrogen (H2) for therapeutic purposes. Hydrogen therapy’s efficacy has not been established; it may help treat neurological disorders by reducing oxidative stress and inflammation, though optimal dosing and targets remain unclear.[1][2] H2 is being researched for age-related disease.[3]

Research

H₂ is proposed to reduce oxidative stress and modulate inflammatory and gene expression pathways, but definitive large-scale clinical evidence of therapeutic efficacy is limited.[2]

H₂ may reduce oxidative stress and influence aging-related pathways, with potential to prevent or treat age-related diseases, though clinical evidence is limited.[3]

It may offer protective benefits in spinal cord injury; clinical evidence is preliminary.[4]

It may protect the liver through antioxidant and anti-inflammatory effects, though clinical evidence is still emerging.[5]

It may improve cardiometabolic health through antioxidant and regulatory effects, though clinical evidence is limited.[6]

References

  1. ^ Wu C, Zou P, Yang L (2023). "Molecular Hydrogen: an Emerging Therapeutic Medical Gas for Brain Disorders". Molecular Neurobiology. 60 (4): 1749–1765. doi:10.1007/s12035-022-03175-w. PMID 36567361.
  2. ^ a b Ohta S (2014). "Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine". Pharmacology & Therapeutics. 144 (1): 1–11. doi:10.1016/j.pharmthera.2014.04.006. PMID 24769081.
  3. ^ a b Fu Z, Zhang J, Zhang Y (2022). "Role of Molecular Hydrogen in Ageing and Ageing-Related Diseases". Oxidative Medicine and Cellular Longevity. 2022 2249749. doi:10.1155/2022/2249749. PMC 8956398. PMID 35340218.
  4. ^ Hu Q, Li Y, Zhao C (2024). "The Molecular Biological Mechanism of Hydrogen Therapy and Its Application in Spinal Cord Injury". Drug Design, Development and Therapy. 18: 1399–1414. doi:10.2147/DDDT.S463177. PMC 11068043. PMID 38707612.
  5. ^ Shi J, Duncan B, Kuang X (2021). "Hydrogen treatment: a novel option in liver diseases". Clinical Medicine. 21 (2): e223–e227. doi:10.7861/clinmed.2020-0370. PMC 8002796. PMID 33762390.
  6. ^ Zhang Y, Tan S, Wang T (2018). "Hydrogen Therapy in Cardiovascular and Metabolic Diseases: from Bench to Bedside". Cellular Physiology and Biochemistry. 47 (1): 1–10. doi:10.1159/000489737. PMID 29763888.
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