Hugo Aguilaniu

Hugo Aguilaniu
Aguilaniu in 2024
Born (1975-10-04) 4 October 1975
Grenoble, France
TitleExecutive Director of Instituto Serrapilheira
Awards
  • CNRS Bronze Medal (2015)
  • ERC Consolidator Grant (2015)
Academic background
Alma mater
ThesisOn protein oxidation, lifespan and aging in Saccharomyces cerevisiae (2003)
Academic advisorThomas Nyström
Academic work
DisciplineMolecular genetics
Sub-disciplineGenetics of ageing
Institutions
Notes

Hugo Aguilaniu (born 4 October 1975) is a French geneticist whose research focuses on the molecular mechanisms of aging[1]. He has been the executive director of the Instituto Serrapilheira in Brazil since 2017 [2].

Biography

Aguilaniu was born in Grenoble, France in 1975 and trained as an agronomist in Bordeaux. In 2003 he obtained his PhD on the molecular genetics of the ageing process from Chalmers University of Technology in Sweden under the supervision of Thomas Nyström, Lena Gustafsson, and Michel Rigoulet.[4]

He then was a postdoctoral fellow at the Salk Institute for Biological Studies (La Jolla, United States) from 2003 to 2006 in Andrew Dillin's lab[5] working on the caloric restriction response in Caenorhabditis elegans[6]. In 2006, he joined the CNRS and became a research director in 2015 [1]. At the École Normale Supérieure de Lyon, he started his own team working on the biology of aging, using experimental models such as the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. His work has examined, in particular, how nutrition affects reproduction and aging.[1] In 2015, he received the CNRS Bronze Medal [7] and an ERC Consolidator Grant.[3]

Aguilaniu's research addresses the genetics of the aging process. He has co-authored studies on the asymmetric inheritance of oxidatively damaged proteins during cell division in yeast,[8] their elimination during reproduction in C. elegans,[9] and the genetic determinants of dietary restriction in that organism.[6][10]

Instituto Serrapilheira

In 2017, Aguilaniu was appointed to lead the Instituto Serrapilheira in Rio de Janeiro, an organization dedicated to supporting scientific research and the public communication of science in Brazil.[11] He has published analyses on strategic issues in research funding and the role of science philanthropy in times of political crisis.[12] He has also emphasized that philanthropy cannot replace public funding, which he describes as the backbone of research financing.[13][14]

Selected publications

  • Aguilaniu, Hugo; Gustafsson, Lena; Rigoulet, Michel; Nyström, Thomas (2003). "Asymmetric inheritance of oxidatively damaged proteins during cytokinesis". Science. 299 (5613).[8]
  • Goudeau, Jérôme; Aguilaniu, Hugo (2010). "Carbonylated proteins are eliminated during reproduction in C. elegans". Aging Cell. 9 (6): 991–1003.[9]
  • Panowski, Siler H.; Wolff, Suzanne; Aguilaniu, Hugo; Durieux, Jenni; Dillin, Andrew (2007). "PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans". Nature. 447 (7144): 550–555.[6]
  • Thondamal, Manjunatha; Witting, Michael; Schmitt-Kopplin, Philippe (2014). "Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans". Nature Communications. 5 (4879). et al.[10]

References

  1. ^ a b c d "Hugo Aguilaniu, geneticist". École normale supérieure de Lyon. 2026. Retrieved 11 February 2026.
  2. ^ a b "Team". Instituto Serrapilheira. 2026. Retrieved 11 February 2026.
  3. ^ a b "Hugo Aguilaniu (Consolidator Grants 2015)". CNRS Biologie (in French). Retrieved 2 February 2026.
  4. ^ "On protein oxidation, lifespan and aging in Saccharomyces cerevisiae". Chalmers Research. Retrieved 18 February 2026.
  5. ^ "Alumni". Dillin Lab (UC Berkeley). Retrieved 18 February 2026.
  6. ^ a b c "PHA-4/Foxa mediates diet-restriction-induced longevity of C. elegans". Nature. 31 May 2007.
  7. ^ "Hugo Aguilaniu". CNRS (in French). Retrieved 18 February 2026.
  8. ^ a b "Asymmetric inheritance of oxidatively damaged proteins during cytokinesis". PubMed.
  9. ^ a b "Carbonylated proteins are eliminated during reproduction in C. elegans". PubMed. December 2010.
  10. ^ a b "Steroid hormone signalling links reproduction to lifespan in dietary-restricted Caenorhabditis elegans". Nature Communications. 11 September 2014.
  11. ^ "Instituto Serrapilheira". Instituto Serrapilheira. Retrieved 18 February 2026.
  12. ^ "Filantropia científica em tempos de crise: lições do Brasil". Stanford Social Innovation Review Brasil (in Portuguese). 12 January 2026.
  13. ^ "Em defesa da ciência". Instituto Serrapilheira (in Portuguese). 20 August 2019.
  14. ^ "Nos países desenvolvidos, o dinheiro que financia a ciência é público". Jornal da USP (in Portuguese). 24 May 2019.
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