Heriaeus melloteei

Heriaeus melloteei
Heriaeus melloteei in Greece
Scientific classification
Kingdom: Animalia
Phylum: Arthropoda
Subphylum: Chelicerata
Class: Arachnida
Order: Araneae
Infraorder: Araneomorphae
Family: Thomisidae
Genus: Heriaeus
Species:
H. melloteei
Binomial name
Heriaeus melloteei
Simon, 1886[1]
Synonyms
  • Heriaeus oblongus[2]

Heriaeus melloteei (also known as Heriaeus oblongus[2]) is a species of crab spider.[3]

Some peptide toxin isolates from the venom of H. melloteei, including those coined Hm-1, Hm-2, and Hm-3, have been shown to inhibit voltage-gated sodium channels in humans.[1][4] The action of Hm-3 in particular, which principally targets the Nav1.4 channel,[5] has led some researchers to propose investigating its applicability in hypokalemic periodic paralysis treatments.[6]

References

  1. ^ a b Billen, Bert; Vassilevski, Alexander; Nikolsky, Anton; Tytgat, Jan; Grishin, Eugene (1 August 2008), "Two novel sodium channel inhibitors from Heriaeus melloteei spider venom differentially interacting with mammalian channel's isoforms", Toxicon, 52 (2): 309–317, doi:10.1016/j.toxicon.2008.05.018, ISSN 0041-0101, archived from the original on 17 December 2021 – via ScienceDirect
  2. ^ a b Staudt, Aloysius (2014), "Zur Bedeutung der Trockenhänge an Maas und Mosel für die Wanderung thermophiler Spinnenarten über Lothringen in die Saar-Region (Arachnida: Araneae)" (PDF), Abhandlungen der Delattinia (in German), 40: 13–48, ISSN 0948-6526, archived from the original (PDF) on 30 December 2025 – via ZOBODAT
  3. ^ Berkut, Antonina A.; Peigneur, Steve; Myshkin, Mikhail Yu.; Paramonov, Alexander S.; Lyukmanova, Ekaterina N.; Arseniev, Alexander S.; Grishin, Eugene V.; Tytgat, Jan; Shenkarev, Zakhar O.; Vassilevski, Alexander A. (2 January 2015), "Structure of Membrane-active Toxin from Crab Spider Heriaeus melloteei Suggests Parallel Evolution of Sodium Channel Gating Modifiers in Araneomorphae and Mygalomorphae*", Journal of Biological Chemistry, 290 (1): 492–504, doi:10.1074/jbc.M114.595678, ISSN 0021-9258 – via ScienceDirect
  4. ^ Nikolsky, A. S.; Billen, B.; Vassilevski, A. A.; Filkin, S. Yu.; Tytgat, J.; Grishin, E. V. (3 September 2009), "Voltage-gated sodium channels are targets for toxins from the venom of the spider Heriaeus melloteei", Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, 3 (3): 245–253, doi:10.1134/S1990747809030027, ISSN 1990-7494
  5. ^ Myshkin, Mikhail Yu; Paramonov, Alexander S.; Kulbatskii, Dmitrii S.; Surkova, Yelizaveta A.; Berkut, Antonina A.; Vassilevski, Alexander A.; Lyukmanova, E. N.; Kirpichnikov, Mikhail P.; Shenkarev, Z. O. (15 March 2021), "Voltage-Sensing Domain of the Third Repeat of Human Skeletal Muscle NaV1.4 Channel As a New Target for Spider Gating Modifier Toxins", Acta Naturae, 13 (1): 134–139, doi:10.32607/actanaturae.11279, ISSN 2075-8251, PMC 8084291
  6. ^ Männikkö, Roope; Shenkarev, Zakhar O.; Thor, Michael G.; Berkut, Antonina A.; Myshkin, Mikhail Yu; Paramonov, Alexander S.; Kulbatskii, Dmitrii S.; Kuzmin, Dmitry A.; Sampedro Castañeda, Marisol; King, Louise; Wilson, Emma R.; Lyukmanova, Ekaterina N.; Kirpichnikov, Mikhail P.; Schorge, Stephanie; Bosmans, Frank (24 April 2018), "Spider toxin inhibits gating pore currents underlying periodic paralysis", Proceedings of the National Academy of Sciences of the United States of America, 115 (17): 4495–4500, doi:10.1073/pnas.1720185115, ISSN 1091-6490, PMC 5924911, PMID 29636418, archived from the original on 6 July 2022
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