Grey's Anatomy season 22

Grey's Anatomy
Season 22
Promotional poster
ShowrunnerMeg Marinis
Starring
No. of episodes14
Release
Original networkABC
Original releaseOctober 9, 2025 (2025-10-09) –
present
Season chronology

The twenty-second season of the American medical drama television series Grey's Anatomy was announced on April 3, 2025, and premiered in the United States on the American Broadcasting Company (ABC) on October 9, 2025.[1][2]

This is the first season not to feature Jake Borelli and Midori Francis as series regulars since the sixteenth and nineteenth seasons, respectively.[3]

Episodes

See also: List of Grey's Anatomy episodes
No.
overall		No. in
season		Title [4]Directed byWritten by [5]Original release date [4]U.S. viewers
(millions)
4491"Only the Strong Survive"Debbie AllenMeg MarinisOctober 9, 2025 (2025-10-09)2.61[6]
After the catastrophic hospital explosion, Grey Sloan's staff scrambles to save not only their patients' lives but also their own. Confronted with impossible surgical decisions and emotional turmoil, they fight to preserve life amid devastation.
4502"We Built This City"Kevin McKiddZoanne ClackOctober 16, 2025 (2025-10-16)2.22[7]
The team at Grey Sloan navigates a chaotic first day of surgical rotations amid hospital renovations. Ben accepts the position of chief resident and Meredith and Maggie spend time with Amelia.
4513"Between Two Lungs"Debbie AllenSandra HamadaOctober 23, 2025 (2025-10-23)2.16[8]
A high-risk lung transplant pushes the surgical team to their limits. Meanwhile, Bailey juggles a trauma patient whose treatment hangs in the balance.
4524"Goodbye Horses"Sammi CannoldJase Miles-PerezOctober 30, 2025 (2025-10-30)2.13[9]
The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.
4535"Sometimes I Feel Like a Motherless Child"Bille WoodruffJess RighthandNovember 6, 2025 (2025-11-06)2.04[10]
Jo navigates a challenging case with a pregnant mother, while Blue and Jules care for a diabetic patient. Meanwhile, Simone treats a patient with a surprising revelation.
4546"When I Crash"Phylicia RashadMichelle LirtzmanNovember 13, 2025 (2025-11-13)1.84[11]
Grey Sloan takes in patients following a catastrophic bus accident. Teddy and Owen have an awkward encounter, and Richard tests Bailey’s patience.
4557"Skyfall"Allison Liddi-BrownCarol BrownJanuary 8, 2026 (2026-01-08)2.04[12]
Winston performs an emergency C-section on Jo, delivering twin girls, but Jo’s cardiomyopathy worsens and she is left in a coma after a cardiac pump is placed. Both newborns are admitted to the NICU; one stabilizes quickly, while the other is treated for a heart murmur. As Link struggles to cope, colleagues rally to support the family. Jo later regains consciousness, and her baby’s condition improves. Elsewhere, Jules Millin confronts her feelings for Winston after treating a critically injured patient but finds him flirting in the bar, while Simone Griffith abandons their celibacy pact and reconnects with Wes. Bailey urges Richard Webber to follow up on his cancer diagnosis, and Lucas Adams grows closer to a terminally ill patient.
4568"Heavy On Me"Lisa LeoneTameson DuffyJanuary 15, 2026 (2026-01-15)2.23[13]
Richard Webber decides to proceed with surgical treatment for his prostate cancer after consulting an outside specialist and reconsidering a watch-and-wait approach. Bailey and Owen lead a multidisciplinary team in the successful removal of a 35-pound abdominal tumor using ECMO support, and Owen proposes expanded trauma training opportunities for residents. Jules Millin reflects on her social detachment and begins engaging more openly with others. Jo Wilson continues recovering from postpartum complications while spending time with her newborn twins in the NICU and identifies eclampsia in another patient, directing emergency treatment that stabilizes the patient.
4579"Fortunate Son"Kim RaverJulie WongJanuary 22, 2026 (2026-01-22)2.45[14]
Richard continues to navigate his health. Meanwhile, Meredith and Nick are visited by Nick’s estranged sister from Boston.
45810"Strip That Down"Kevin McKiddMin-Woo ParkJanuary 29, 2026 (2026-01-29)2.44[15]
Addison Montgomery returns to Grey Sloan, seeking assistance with a patient with a neurological condition. Bailey joins Owen and Blue on a paramedic ride-along.
45911"(If You Want It) Do It Yourself"Linda KleinScott D. BrownFebruary 26, 2026 (2026-02-26)2.25[17]
Teddy and Winston clash over a case, while Owen and Jules treat a urologist. Lucas struggles with prioritizing patients.
This episode is dedicated to the memory of Eric Dane, (who portrayed Dr. Mark Sloan), who died of amyotrophic lateral sclerosis (ALS) on February 19, 2026.[16]
46012"Get Lucky"Chandra WilsonJess RighthandMarch 5, 2026 (2026-03-05)2.15[18]
Tensions rise as Teddy and Winston take on a complex procedure, while Kavita and Ben try and impress the new plastics attending. Jo and Link leave the babies with a nanny for the first time.
46113"Love the Way You Lie"Allison Liddi-BrownSophia ArnaoMarch 12, 2026 (2026-03-12)2.22[19]
Richard tackles a shocking case on his first day back, while Kavita and Jules prepare for a high-stakes presentation. Bailey must have a difficult conversation with a beloved patient, and Jo works to baby-proof the loft.
46214"Wrecking Ball"Kevin McKiddMichelle LirtzmanMarch 19, 2026 (2026-03-19)TBD
A couple lands in the hospital with life-altering injuries after a wrecking ball destroys their home. Lucas and Simone struggle to support a young, terminally ill patient, and Richard hosts a prostate screening event.
46315"Take Me to the River"TBAJase Miles-PerezMarch 26, 2026 (2026-03-26)TBD
Bailey and Blue are forced to confront the emotional costs of experimental care. Meanwhile, Owen, Teddy, Simone and Dani help out at a busy rural hospital, and Richard attempts to spread information about early prostate screenings to the community.
46416"Feel It Still"Jake Borelli[20]Julie WongApril 2, 2026 (2026-04-02)TBD
Jo returns for her first full day back from leave, and Owen struggles to keep it together when someone close to him is admitted to Grey Sloan. Meanwhile, Bailey navigates hospital leadership.
46517TBATBATBAApril 30, 2026 (2026-04-30)TBD
46618TBAKevin MckiddMeg MarinisMay 2026 (2026-05)TBD

Cast and characters

See also: List of Grey's Anatomy cast members and List of Grey's Anatomy characters

Main

Recurring

Notable guests

Production

Development

On April 3, 2025, ABC renewed the series for a twenty-second season with Meg Marinis' third year as showrunner.[1] The season consists of 18 episodes, consistent with the episode order of Season 21.[25] It surpassed the 450 episode mark during episode 2, extending its record as the longest-running American primetime medical drama.[26] Filming began on August 1.[27] Season 22 premiered in the United States on October 9, 2025.[28]

Casting

Ellen Pompeo will continue to narrate the series and receive star billing, appearing in seven episodes, as she did in Season 21.[29] Chandra Wilson and James Pickens Jr. remain the only original cast members confirmed to appear in all 18 episodes.[30] On October 9, 2025, Trevor Jackson, who guest starred as Dr. Wes Bryant in the last two episodes of Season 21, was promoted to a series regular.[21]

Continuing from last season, the minimum episode guarantee for most series regulars was reduced to 14 out of 18 episodes. However, longtime cast member Caterina Scorsone's role was further scaled back, resulting in a total of 11 appearances for the season. Following her character's sabbatical in episode two, Scorsone was absent for seven episodes, returning for episode 10 in January 2026.[31]

In November 2025, James Pickens Jr. opened up about his prostate cancer diagnosis, which now mirrors the storyline of his character Dr. Richard Webber, who revealed he has cancer in the mid-season finale. Subsequently, he announced being cancer-free.[32][33]

In December 2025, it was revealed that Kate Walsh will reprise her role as Dr. Addison Montgomery in episode 10, titled "Strip That Down", airing January 29, 2026.[24]

Future

In February 2026, Grey's Anatomy was reported to likely receive a 23rd season renewal from ABC. The potential renewal was said to involve additional budget reductions, which could affect the episode order and cast. In recent seasons, veteran cast members had already seen their episode guarantees reduced as part of cost-cutting measures, and further cast departures were described as possible.[34]

Reception

Ratings

Viewership and ratings per episode of Grey's Anatomy season 22
No. Title Air date Timeslot (ET) Rating/share
(18–49)		 Viewers
(millions)		 DVR
(18–49)		 DVR viewers
(millions)		 Total
(18–49)		 Total viewers
(millions)		 Ref.
1 "Only the Strong Survive" October 9, 2025 Thursday 10:00 p.m. 0.3/3 2.61 0.2 1.74 0.4 5.20 [6]
2 "We Built This City" October 16, 2025 0.2/2 2.20 0.3 1.68 0.4 3.90 [7]
3 "Between Two Lungs" October 23, 2025 0.2/3 2.16 0.2 1.56 0.5 3.73 [8]
4 "Goodbye Horses" October 30, 2025 0.2/3 2.13 0.2 1.24 0.4 3.37 [9]
5 "Sometimes I Feel Like a Motherless Child" November 6, 2025 0.2/2 2.04 0.2 1.03 0.3 3.07 [10]
6 "When I Crash" November 13, 2025 0.1/2 1.84 N/a N/a N/a N/a [11]
7 "Skyfall" January 8, 2026 0.2/2 2.04 N/a N/a N/a N/a [12]
8 "Heavy On Me" January 15, 2026 0.2/3 2.23 N/a N/a N/a N/a [13]
9 "Fortunate Son" January 22, 2026 0.2/3 2.45 N/a N/a N/a N/a [14]
10 "Strip That Down" January 29, 2026 0.2/3 2.44 N/a N/a N/a N/a [15]
11 "(If You Want It) Do It Yourself" February 26, 2026 0.2/3 2.25 N/a N/a N/a N/a [17]
12 "Get Lucky" March 5, 2026 0.2/3 2.15 N/a N/a N/a N/a [18]
13 "Love the Way You Lie" March 12, 2026 0.2/3 2.22 N/a N/a N/a N/a [19]

References

  1. ^ a b Otterson, Joe (April 3, 2025). "'9-1-1,' 'Grey's Anatomy,' 'The Rookie,' 'Shifting Gears,' 'Will Trent' Renewed at ABC". Variety. Retrieved July 15, 2025.
  2. ^ White, Peter (July 29, 2025). "ABC Moves Up 'Grey's Anatomy', '9-1-1' & '9-1-1: Nashville' Premiere Dates". Deadline Hollywood. Retrieved July 29, 2025.
  3. ^ Venable, Malcom (December 4, 2024). "'Grey's Anatomy' Showrunner Meg Marinis on That Shocking Mid-Season Finale, Two Big Departures, and What's Coming Next". Shondaland. Retrieved July 22, 2025.
  4. ^ a b "Shows A-Z – Grey's Anatomy on ABC". The Futon Critic. Retrieved March 5, 2026.
  5. ^ "Grey's Anatomy". Writers Guild of America West. Retrieved February 5, 2026.
  6. ^ a b Pucci, Douglas (October 10, 2025). "Thursday Ratings: 9-1-1: Nashville on ABC Has Okay Debut". Programming Insider. Retrieved October 14, 2025.
  7. ^ a b Pucci, Douglas (October 17, 2025). "Thursday Ratings: CBS Leads Broadcast Networks Among Total Viewers, Year-Over-Year Erosion in Key Demos for Linear Overall". Programming Insider. Retrieved October 20, 2025.
  8. ^ a b Pucci, Douglas (October 27, 2025). "Thursday Ratings: Ghosts on CBS Earns Top 18-49 and 25-54 Demos Among Prime Time Broadcast Network Telecasts". Programming Insider. Retrieved October 27, 2025.
  9. ^ a b Pucci, Douglas (October 31, 2025). "Thursday Ratings: CBS and ABC Battle for Demo Supremacy Among Broadcast Networks". Programming Insider. Retrieved November 3, 2025.
  10. ^ a b Pucci, Douglas (November 7, 2025). "Thursday Ratings: NBC Musical Special Wicked: One Wonderful Night Tops its Time Slot In Demos Among Broadcast Shows". Programming Insider. Retrieved November 10, 2025.
  11. ^ a b Pucci, Douglas (November 17, 2025). "Thursday Ratings: 26th Annual Latin Grammy Awards Televised on Univision". Programming Insider. Retrieved November 17, 2025.
  12. ^ a b Berman, Marc (January 12, 2026). "Thursday Scorecard: ABC Granddaddy Grey's Anatomy Plummets to Just 2-Million Viewers". Programming Insider.
  13. ^ a b Berman, Marc (January 20, 2026). "Thursday Scorecard: Return of Fox Comedies Animal Control and Going Dutch Left at the Starting Gate". Programming Insider.
  14. ^ a b Berman, Marc (January 26, 2026). "Thursday Scorecard: ABC and NBC Neck and Neck for Modest Dominance; Veteran Grey's Anatomy Continues to Lose Steam". Programming Insider.
  15. ^ a b Berman, Marc (February 2, 2026). "Thursday Ratings: ABC and NBC Share Leadership; ABC's 9-1-1 and 9-1-1: Nashville Solid". Programming Insider. Archived from the original on February 3, 2026.
  16. ^ Barnes, Mike (February 19, 2026). "Eric Dane, Dr. Mark "McSteamy" Sloan on Grey's Anatomy, Dies at 53". The Hollywood Reporter. Retrieved February 26, 2026.
  17. ^ a b Berman, Marc (March 2, 2026). "Thursday Ratings: The Return of CBS' Line-up Tops Night in Total Viewers". Programming Insider. Archived from the original on March 2, 2026.
  18. ^ a b Berman, Marc (March 9, 2026). "Thursday Scorecard: 'Georgie & Mandy's First Marriage' on CBS Tops Evening". Programming Insider. Archived from the original on March 9, 2026.
  19. ^ a b Berman, Marc (March 16, 2026). "Thursday Ratings: The Big 3 Share Leadership – CBS Tops in Viewers; ABC and NBC No. 1 in Adults 18-49". Programming Insider.{{cite web}}: CS1 maint: url-status (link)
  20. ^ Andreeva, Nellie (March 20, 2026). "Jake Borelli Returns To 'Grey's Anatomy' As Director". Deadline. Retrieved March 20, 2026.
  21. ^ a b c d Andreeva, Nellie (October 9, 2025). "'Grey's Anatomy' Ups Trevor Jackson To Series Regular, Adds Jade Pettyjohn & Anita Kalathara As Recurring For Season 22'". Deadline Hollywood. Retrieved October 9, 2025.
  22. ^ Roots, Kimberly; Swift, Andy; Matt, Mitovich; Nemetz, Dave; Franken, Claire; Schwartz, Ryan; Caruso, Nick; Mason, Charlie (September 10, 2025). "Fall TV Preview 2025: Exclusive Scoop and Photos on 30+ Returning Favorites!". TVLine. Retrieved September 11, 2025.
  23. ^ Swift, Andy (October 23, 2025). "Sophia Bush Returns To Grey's Anatomy — Watch Cass' Awkward Reunion With Teddy (Exclusive)". TVLine. Retrieved October 23, 2025.
  24. ^ a b Otterson, Joe (December 4, 2025). "Kate Walsh Returning to 'Grey's Anatomy' as Season 22 Guest Star (EXCLUSIVE)". Variety. Retrieved December 4, 2025.
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  27. ^ Camilla Luddington [@camillaluddington]; (July 31, 2025). "Backstory… Tonight I'm re-watching the season finale again to prepare for filming tmw. And suddenly.. Matt decides he needs to blend a smoothie. At 8pm.. during this scene.. I had to start recording 😂". Retrieved August 10, 2025 – via Instagram.
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  32. ^ Garner, Glenn (November 15, 2025). "'Grey's Anatomy's James Pickens Jr. Reveals Prostate Cancer Diagnosis". Deadline Hollywood. Retrieved November 16, 2025.
  33. ^ Heching, Dan (November 14, 2025). "'Grey's Anatomy' star James Pickens Jr. opens up about his prostate cancer diagnosis, touts early detection". CNN. Retrieved November 16, 2025.
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