GRAM domain
| GRAM domain | |||||||
|---|---|---|---|---|---|---|---|
Myotubularin-related protein 2 | |||||||
| Identifiers | |||||||
| Symbol | GRAM | ||||||
| Pfam | PF02893 | ||||||
| Pfam clan | CL0266 | ||||||
| InterPro | IPR004182 | ||||||
| SMART | GRAM | ||||||
| SCOP2 | 1lw3 / SCOPe / SUPFAM | ||||||
| OPM superfamily | 130 | ||||||
| OPM protein | 1zvr | ||||||
| CDD | cd10570 | ||||||
| Membranome | 349 | ||||||
| |||||||
The GRAM domain is found in glucosyltransferases, myotubularins and other membrane-associated proteins.[1] The structure of the GRAM domain is similar to that found in PH domains.[2]
Proteins containing GRAM domains are found in all eukaryotes and bacteria, but not archaea.[3] Various GRAM domains can bind proteins or lipids.[3]
Human proteins containing this domain
GRAMD1A; GRAMD1B; GRAMD1C; GRAMD2A; GRAMD2B; GRAMD4; MTM1; MTMR1; MTMR2; NCOA7; NSMAF; OXR1; SBF1; SBF2; TBC1D8; TBC1D8B; TBC1D9; TBC1D9B; WBP2; WBP2NL; dJ439F8.1;
References
- ^ Doerks T, Strauss M, Brendel M, Bork P (October 2000). "GRAM, a novel domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins". Trends Biochem. Sci. 25 (10): 483–5. doi:10.1016/S0968-0004(00)01664-9. PMID 11050430.
- ^ Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA (December 2003). "Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome". Mol. Cell. 12 (6): 1391–402. doi:10.1016/S1097-2765(03)00486-6. PMID 14690594.
- ^ a b Jiang SY, Ramamoorthy R, Ramachandran S (February 2008). "Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes". Dev. Biol. 314 (2): 418–32. doi:10.1016/j.ydbio.2007.11.031. PMID 18201690.