Fumonisin

Fumonisin refers to any one of a class of related chemical structures, the fumonisins, that constitute a group of fungal mycotoxins originally identified with genus Fusarium, a mycotoxin known for its contamination of infested corn seed[1] (as well as other plants and foodstuffs), the infecting species, in particular, being within Fusarium's Liseola section.[2] As shown in the example in the figure (of fumonisin B1), members of the family are composed of a central "chai[n] of about 20 carbons", and bear an "acidic ester, acetylamino and sometimes other substituents".[1] The fumonisins inhibit ceramide synthetase an enzyme that converts sphingolipids to ceramides.[1]

Family background

As of 2000, 15 different fumonisins had been reported, and other minor metabolites have been characterized.[3] More specifically, the term refers primarily to the family of compounds that includes the widely studied fumonisins B1, B2, B3, and B4, as well as others. As chemical agents, the fumonisins are distinct from the large family of Fusarium trichothecene (T-2-type) mycotoxins,[4] and from the Fusarium estrogenic metabolite, zearalenone, an F-2-type mycotoxin.[5]

In 2015, a unique supposed class of non-aminated fumonisins was reported on grapes infected with Aspergillus welwitschiae, where toxicities have not yet been established.[6]

Mechanisms of toxicity

The fumonisins inhibit ceramide synthetase (sphingosine N-acyltransferase), an enzyme that converts sphingolipids to ceramides.[1]

Other research

Suggestion has appeared that the fumonisins are not genotoxic, and so might belong to the peroxisome proliferator class of non-genotoxic carcinogens.[7]

References

  1. ^ a b c d NLM Staff (2020-05-27). "Fumonisins". MeSH Descriptor Data 2025 (MeSHb.NLM.NIH.gov). Retrieved 5 January 2025.
  2. ^ Blandino M; Scarpino V; Testa G; Vanara F & Reyneri A (2022-06-21). "The Effect of Foliar Fungicide and Insecticide Application on the Contamination of Fumonisins, Moniliformin and Deoxynivalenol in Maize Used for Food Purposes". Toxins (Basel). 14 (7): 422. doi:10.3390/toxins14070422. PMC 9316389. PMID 35878160.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ Marasas, W.F.O.; J.D. Miller; R.T. Riley; A. Visconti (2000). Environmental Health Criteria 219: Fumonisin B1. Vammala, Finland: World Health Organization. p. 9. ISBN 9241572191.
  4. ^ USAMRIID Staff (April 2005). Woods, Lt Col Jon B. (ed.). "USAMRIID's Medical Management of Biological Casualties Handbook" (PDF) (6th ed.). Fort Detrick, MD: U.S. Army Medical Research Institute, Institute of Infectious Diseases (USAMRIID). pp. 101–104. Retrieved 5 January 2026.
  5. ^ Marasas, W.F.O.; Paul E. Nelson (1987). Mycotoxicology: Introduction to the Mycology, Plant Pathology, Chemistry, Toxicology, and Pathology of Naturally Occurring Mycotoxicoses In Animals and Man. University Park, PA: The Pennsylvania State University Press. p. 47f. ISBN 0271004428. Retrieved 6 January 2025.
  6. ^ Renaud, J.B.R; M.J Kelman; Tianyu F. Qi; K.A. Seifert; M.W. Sumarah (2015). "Product Ion Filtering with Rapid Polarity Switching for the Detection of All Fumonisins and AAL-toxins". Rapid Communications in Mass Spectrometry. 29 (22). Rapid Communications in Mass Spectrometry Volume 29, Issue 22, 30 November 2015, Pages 2131–2139: 2131–2139. Bibcode:2015RCMS...29.2131R. doi:10.1002/rcm.7374. PMID 26467225.
  7. ^ Jackson, Lauren S.; DeVries, Jonathan W.; Bullerman, Lloyd B. (1996). Fumonisins In Food. New York, NY: Plenum Press. p. 289. ISBN 0306452162.
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