Flavanone 7-O-beta-glucosyltransferase
| Flavanone 7-O-beta-glucosyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.185 | ||||||||
| CAS no. | 125752-73-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Flavanone 7-O-beta-glucosyltransferase (EC 2.4.1.185) is an enzyme that catalyzes the chemical reaction
- UDP-glucose + a flavanone UDP + a flavanone 7-O-beta-D-glucoside
The two substrates of this enzyme are UDP-glucose and a flavanone. Its products are UDP and the corresponding flavanone 7-O-beta-D-glucoside.[1][2]
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:flavanone 7-O-beta-D-glucosyltransferase. Other names in common use include uridine diphosphoglucose-flavanone 7-O-glucosyltransferase, naringenin 7-O-glucosyltransferase, and hesperetin 7-O-glucosyl-transferase.[1]
An example of this reaction in flavonoid biosynthesis is the conversion of naringenin to prunin:[3]
In some citrus fruits, the product prunin is converted to naringin, a compound which is responsible for the bitter taste of grapefruit.[3][4]
References
- ^ a b Enzyme 2.4.1.185 at KEGG Pathway Database.
- ^ McIntosh CA, Latchinian L, Mansell RL (1990). "Flavanone-specific 7-O-glucosyltransferase activity in Citrus paradisi seedlings: purification and characterization". Arch. Biochem. Biophys. 282 (1): 50–7. doi:10.1016/0003-9861(90)90085-D. PMID 2171434.
- ^ a b McIntosh CA; Mansell RL (1990). "Biosynthesis of naringin in Citrus paradisi - UDP-glucosyl-transferase activity in grapefruit seedlings". Phytochemistry. 29 (5): 1533–1538. Bibcode:1990PChem..29.1533M. doi:10.1016/0031-9422(90)80115-W.
- ^ Alam MA, Subhan N, Rahman MM, Uddin SJ, Reza HM, Sarker SD (July 2014). "Effect of Citrus Flavonoids, Naringin and Naringenin, on Metabolic Syndrome and Their Mechanisms of Action". Advances in Nutrition. 5 (4): 404–417. doi:10.3945/an.113.005603. ISSN 2156-5376. PMC 4085189. PMID 25022990.