Endoplasmic reticulum resident protein 27 is a protein that in humans is encoded by the ERP27 gene. It is a homologue of PDI (protein disulfide-isomerase), localised to the Endoplasmic Reticulum. The structure of ERp27 has been solved by both X-ray crystallography and NMR spectroscopy,[5] showing it to be composed of two thioredoxin-like domains with homology to the non-catalytic b and b' domains of PDI. The function of ERp27 is unknown, but on the basis of its homology with PDI it is thought to possess chaperone activity.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000139055 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030219 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Amin NT, Wallis AK, Wells SA, Rowe ML, Williamson RA, Howard MJ, et al. (March 2013). "High-resolution NMR studies of structure and dynamics of human ERp27 indicate extensive interdomain flexibility". The Biochemical Journal. 450 (2): 321–332. doi:10.1042/BJ20121635. PMC 4203274. PMID 23234573.
- ^ Galligan JJ, Petersen DR (July 2012). "The human protein disulfide isomerase gene family". Human Genomics. 6 (1) 6. doi:10.1186/1479-7364-6-6. PMC 3500226. PMID 23245351.