+ electron-transferring
flavoprotein
Dimethylglycine dehydrogenase
| Dimethylglycine dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.5.8.4 | ||||||||
| CAS no. | 37256-30-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Dimethylglycine dehydrogenase (EC 1.5.8.4) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are dimethylglycine, water and an electron-transferring flavoprotein. Its products are sarcosine, formaldehyde, and the reduced flavoprotein.[1][2][3]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N,N-dimethylglycine:acceptor oxidoreductase (demethylating). Other names in common use include N,N-dimethylglycine oxidase, and N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine and threonine metabolism. It employs one cofactor, flavin adenine dinucleotide.[1]
References
- ^ a b Enzyme 1.5.8.4 at KEGG Pathway Database.
- ^ Hoskins DD, Mackenzie CG (1961). "Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 236: 177–83. doi:10.1016/S0021-9258(18)64450-3. PMID 13716069.
- ^ Frisell WR, Mackenzie CG (1962). "Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 237: 94–8. doi:10.1016/S0021-9258(18)81367-9. PMID 13895406.