Dimethylamine dehydrogenase

Dimethylamine dehydrogenase
Identifiers
EC no.1.5.8.1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins

Dimethylamine dehydrogenase (EC 1.5.8.1) is an enzyme that catalyzes the chemical reaction

 
H2O
 
H2O
 
 
+
 
+ reduced
flavoprotein
 

The three substrates of this enzyme are dimethylamine, water, and an electron-transferring flavoprotein. Its products are methylamine, formaldehyde, and the reduced flavoprotein.[1][2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with a flavin as acceptor. The systematic name of this enzyme class is dimethylamine:electron-transferring flavoprotein oxidoreductase. It uses one cofactor, flavin mononucleotide.

References

  1. ^ Enzyme 1.5.8.1 at KEGG Pathway Database.
  2. ^ Yang CC, Packman LC, Scrutton NS (1995). "The primary structure of Hyphomicrobium X dimethylamine dehydrogenase. Relationship to trimethylamine dehydrogenase and implications for substrate recognition". Eur. J. Biochem. 232 (1): 264–71. doi:10.1111/j.1432-1033.1995.tb20808.x. PMID 7556160.