Dimethomorph

Dimethomorph
Names
	IUPAC name 3-(4-chlorophenyl)-3-(3,4-dimethoxyphenyl)-1-morpholin-4-ylprop-2-en-1-one
Identifiers
CAS Number	110488-70-5 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:81848;
ChEMBL	ChEMBL1870371;
ChemSpider	4735560;
ECHA InfoCard	100.100.586
EC Number	404-200-2;
KEGG	C18583;
PubChem CID	5889665;
UNII	3EXL2158GV ;
CompTox Dashboard (EPA)	DTXSID7034545 ;
	InChI InChI=1S/C21H22ClNO4/c1-25-19-8-5-16(13-20(19)26-2)18(15-3-6-17(22)7-4-15)14-21(24)23-9-11-27-12-10-23/h3-8,13-14H,9-12H2,1-2H3/b18-14+ Key: QNBTYORWCCMPQP-NBVRZTHBSA-N;
	SMILES O=C(\C=C(/c1ccc(Cl)cc1)c2ccc(OC)c(OC)c2)N3CCOCC3;
Properties
Chemical formula	C21H22ClNO4
Molar mass	387.86 g·mol−1
Melting point	137.2 °C (279.0 °F; 410.3 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Dimethomorph is a fungicide with systemic function. It is used for treating mildew and root rot caused by fungi such as those in the genera Pythium and Phytophthora.^[1]

Prohibition in the European Union

In April 2024, the European Union did not renew its approval for the use of dimethomorph, after the European Food Safety Authority identified several areas of concern. In particular, dimethomorph has been classified as toxic to reproduction.^[2]

References

^ Ojiambo, P. S.; Paul, P. A.; Holmes, G. J. (2010). "A quantitative review of fungicide efficacy for managing downy mildew in cucurbits". Phytopathology. 100 (10): 1066–76. doi:10.1094/PHYTO-12-09-0348. PMID 20839942.
^ Commission Implementing Regulation (EU) 2024/1207 of 29 April 2024 concerning the non-renewal of the approval of the active substance dimethomorph, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council, and amending Commission Implementing Regulation (EU) No 540/2011

[1] Ojiambo, P. S.; Paul, P. A.; Holmes, G. J. (2010). "A quantitative review of fungicide efficacy for managing downy mildew in cucurbits". Phytopathology. 100 (10): 1066–76. doi:10.1094/PHYTO-12-09-0348. PMID 20839942.

[2] Commission Implementing Regulation (EU) 2024/1207 of 29 April 2024 concerning the non-renewal of the approval of the active substance dimethomorph, in accordance with Regulation (EC) No 1107/2009 of the European Parliament and of the Council, and amending Commission Implementing Regulation (EU) No 540/2011

[1]

[2]