Diane Joseph-McCarthy
Diane Joseph-McCarthy | |
|---|---|
| Alma mater | Boston University (BA), Massachusetts Institute of Technology (PhD) |
| Known for | Computational approaches to drug discovery, molecular modeling, fragment-based lead discovery |
| Awards | Fellow of the American Institute for Medical and Biological Engineering (2023) |
| Scientific career | |
| Fields | Biomedical engineering, Computational chemistry, Drug discovery |
| Institutions | Boston University; EnBiotix; AstraZeneca |
Diane Joseph-McCarthy is an American biomedical engineer whose work focuses on computational approaches to drug discovery. She serves as Executive Director of the Bioengineering Technology & Entrepreneurship Center (BTEC) and Professor of Practice in Biomedical Engineering at Boston University [1]
Early life and education
After graduating from Boston University with a Bachelor of Arts degree, Joseph-McCarthy went on to the Massachusetts Institute of Technology to obtain a PhD under Professor Gregory A. Petsko and Martin Karplus. After that, she worked as a postdoctoral researcher at Harvard Medical School and Harvard University.[2]
Career
Joseph-McCarthy has worked in both academic and industrial settings in the fields of computational chemistry and drug discovery. Earlier in her career, she was employed in the pharmaceutical and biotechnology sectors.[2] While working for AstraZeneca in the Infection Innovative Medicines & Early Development unit, she participated in research projects related to the creation of antimicrobial medications.[3]
Later, she became Vice President of Translational Science and then Senior Vice President of Discovery and Early Development at EnBiotix.[3]
Later on, Joseph-McCarthy joined Boston University, where she is currently the Executive Director of the Bioengineering Technology & Entrepreneurship Center (BTEC). The program supports bioengineering and translational science research and entrepreneurship projects.[1]
Research
Joseph-McCarthy's research has focused on computer methods used in drug discovery and molecular modelling. Her work has looked at protein-ligand interactions, structure-based ligand design, and fragment-based lead discovery. She has also contributed to studies on predicting protein binding sites and identifying antibody-binding epitopes using computational techniques.[4][5][6]
Awards and recognition
In 2023, Joseph-McCarthy was elected a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), which recognizes contributions to medical and biological engineering.[1]
Selected publications
- Joseph-McCarthy, Diane (1999). "Computational approaches to structure-based ligand design". Pharmacology & Therapeutics. 84 (2): 179–191. doi:10.1016/s0163-7258(99)00031-5. PMID 10596905.
- Joseph, D.; Petsko, G. A.; Karplus, M. (1990-09-21). "Anatomy of a conformational change: hinged "lid" motion of the triosephosphate isomerase loop". Science. 249 (4975): 1425–1428. Bibcode:1990Sci...249.1425J. doi:10.1126/science.2402636. PMID 2402636.
- MacKerell, A. D.; Bashford, D.; Bellott, M.; Dunbrack, R. L.; Evanseck, J. D.; Field, M. J.; Fischer, S.; Gao, J.; Guo, H.; Ha, S.; Joseph-McCarthy, D.; Kuchnir, L.; Kuczera, K.; Lau, F. T.; Mattos, C. (1998-04-30). "All-atom empirical potential for molecular modeling and dynamics studies of proteins". The Journal of Physical Chemistry. B. 102 (18): 3586–3616. Bibcode:1998JPCB..102.3586M. doi:10.1021/jp973084f. PMID 24889800.
- Joseph-McCarthy, Diane; Campbell, Arthur J.; Kern, Gunther; Moustakas, Demetri (2014-03-24). "Fragment-based lead discovery and design". Journal of Chemical Information and Modeling. 54 (3): 693–704. doi:10.1021/ci400731w. PMID 24490951.
References
- ^ a b c "Three More AIMBE Fellows from ENG | College of Engineering". www.bu.edu. Retrieved 2026-03-02.
- ^ a b Lazou, Maria; Kozakov, Dima; Joseph-McCarthy, Diane; Vajda, Sandor (2024-11-01). "Which cryptic sites are feasible drug targets?". Drug Discovery Today. 29 (11) 104197. doi:10.1016/j.drudis.2024.104197. PMC 11568903. PMID 39368697.
- ^ a b "EnBiotix Reports Publication Highlighting Anti-Persister Agent Targeting Antibiotic-Tolerant Infections in Antimicrobial Agents and Chemotherapy". 2 October 2017.
- ^ Joseph-McCarthy, Diane; Campbell, Arthur J.; Kern, Gunther; Moustakas, Demetri (2014-03-24). "Fragment-based lead discovery and design". Journal of Chemical Information and Modeling. 54 (3): 693–704. doi:10.1021/ci400731w. PMID 24490951.
- ^ "Diane Joseph-McCarthy | Institute for Excellence in Teaching & Learning". www.bu.edu. Retrieved 2026-03-02.
- ^ Li, Rang; Wilderotter, Sabrina; Stoddard, Madison; Van Egeren, Debra; Chakravarty, Arijit; Joseph-McCarthy, Diane (2024). "Computational identification of antibody-binding epitopes from mimotope datasets". Frontiers in Bioinformatics. 4 1295972. doi:10.3389/fbinf.2024.1295972. PMC 10920257. PMID 38463209.