Demethylrebeccamycin-D-glucose O-methyltransferase
| Demethylrebeccamycin-D-glucose O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.164 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Demethylrebeccamycin-D-glucose O-methyltransferase (EC 2.1.1.164, RebM) is an enzyme with systematic name S-adenosyl-L-methionine:demethylrebeccamycin-D-glucose O-methyltransferase.[1][2] This enzyme catalyses the following chemical reaction
This is the final step in the biosynthesis of rebeccamycin, an indolocarbazole alkaloid isolated from Nocardia bacteria.[3][4] It uses S-adenosyl methionine as a cofactor.[5]
References
- ^ Zhang C, Albermann C, Fu X, Peters NR, Chisholm JD, Zhang G, Gilbert EJ, Wang PG, Van Vranken DL, Thorson JS (May 2006). "RebG- and RebM-catalyzed indolocarbazole diversification". ChemBioChem. 7 (5): 795–804. doi:10.1002/cbic.200500504. PMID 16575939. S2CID 25017820.
- ^ Singh S, McCoy JG, Zhang C, Bingman CA, Phillips GN, Thorson JS (August 2008). "Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebM". The Journal of Biological Chemistry. 283 (33): 22628–36. doi:10.1074/jbc.M800503200. PMC 2504894. PMID 18502766.
- ^ Bush JA, Long BH, Catino JJ, Bradner WT, Tomita K (May 1987). "Production and biological activity of rebeccamycin, a novel antitumor agent". The Journal of Antibiotics. 40 (5): 668–78. doi:10.7164/antibiotics.40.668. PMID 3112080.
- ^ Pommerehne, Kathrin; Walisko, Jana; Ebersbach, Anna; Krull, Rainer (2019). "The antitumor antibiotic rebeccamycin—challenges and advanced approaches in production processes". Applied Microbiology and Biotechnology. 103 (9): 3627–3636. doi:10.1007/s00253-019-09741-y. PMID 30888461.
- ^ Enzyme 2.1.1.164 at KEGG Pathway Database.
External links
- Demethylrebeccamycin-D-glucose+O-methyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)