Daf-4
| abnormal dauer formation protein 4 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-4 | ||||||
| Entrez | 175781 | ||||||
| HomoloGene | 124563 | ||||||
| UniProt | P50488 | ||||||
| Other data | |||||||
| Chromosome | III: 5.63 - 5.63 Mb | ||||||
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The DAF-4 gene encodes for the only type II receptor of TGF-beta signaling pathway in the worm Caenorhabditis elegans,[1] with the ligands Daf-7 or Dbl-1.[2] When binds to the ligand Daf-7, Daf-4 complexed with the type I receptor Daf-1, and activated the Smad Protein Daf-8/14. By contrast, when binds to Dbl-1, Daf-4 complexed with the Sma-6 type I receptor, and activated the Sma-2/3/4.[3]
References
- ^ Estevez, M; Attisano, L; Wrana, J; Albert, PS; Massagué, J; Riddle, DL (October 1993). "The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development". Nature. 365: 644–649. doi:10.1038/365644a0.
- ^ Savage C, Das P, Finelli AL, Townsend SR, Sun CY, Baird SE, Padgett RW (January 1996). "Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components". Proceedings of the National Academy of Sciences of the United States of America. 93 (2): 790–4. Bibcode:1996PNAS...93..790S. doi:10.1073/pnas.93.2.790. PMC 40134. PMID 8570636.
- ^ Krishna S, Maduzia LL, Padgett RW (January 1999). "Specificity of TGFbeta signaling is conferred by distinct type I receptors and their associated SMAD proteins in Caenorhabditis elegans". Development. 126 (2): 251–60. doi:10.1242/dev.126.2.251. PMID 9847239. S2CID 2460114.