Caspase 4

CASP4
Identifiers
Aliases	CASP4, ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX, Mih1, caspase 4
External IDs	OMIM: 602664; MGI: 107700; HomoloGene: 136493; GeneCards: CASP4; OMA:CASP4 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	104,969,366 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	5,336,783 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; Achilles tendon; ; upper lobe of left lung; ; body of pancreas; ; gallbladder; ; right lung; ; spleen; ; epithelium of colon;
	Top expressed in
	granulocyte; ; jejunum; ; ileum; ; duodenum; ; large intestine; ; Paneth cell; ; colon; ; endothelial cell of lymphatic vessel; ; uterus; ; intestinal villus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; peptidase activity; hydrolase activity; cysteine-type endopeptidase activity involved in execution phase of apoptosis; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity; CARD domain binding; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; protein binding;
Cellular component	NLRP3 inflammasome complex; cytoplasm; endoplasmic reticulum membrane; membrane; extracellular region; AIM2 inflammasome complex; IPAF inflammasome complex; endoplasmic reticulum; mitochondrion; inflammasome complex; cytosol; plasma membrane; protein-containing complex;
Biological process	regulation of apoptotic process; programmed cell death; immune system process; proteolysis; intrinsic apoptotic signaling pathway; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; regulation of inflammatory response; innate immune response; inflammatory response; cellular response to amyloid-beta; apoptotic process; execution phase of apoptosis; positive regulation of tumor necrosis factor-mediated signaling pathway; activation of cysteine-type endopeptidase activity involved in apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	837
	12363
	ENSG00000196954
	ENSMUSG00000033538
	P49662
	P70343
	NM_001225; NM_033306; NM_033307
	NM_007609
	NP_001216; NP_150649
NP_031635; NP_001366247; NP_001366248; NP_001366249; NP_001366250;
	NP_001366251; NP_001366252
	Wikidata
View/Edit Human	View/Edit Mouse

Caspase 4 is an enzyme that in human is encoded by the CASP4 gene.

Caspase 4 proteolytically cleaves other proteins at an aspartic acid residue (LEVD-), and belongs to a family of cysteine proteases called caspases. The function of caspase 4 is not fully known, but it is believed to be an inflammatory caspase, along with caspase 1, caspase 5 (and the murine homolog caspase 11), with a role in the immune system.^[5]

The anti-inflammatory drug indoprofen is an inhibitor of the activity of the caspase-4 enzyme.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196954 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033538 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.
^ Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi:10.1016/j.chembiol.2017.02.003. PMC 5357154. PMID 28238723.

External links

The MEROPS online database for peptidases and their inhibitors: C14.007

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196954 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033538 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Martinon F, Tschopp J (2007). "Inflammatory caspases and inflammasomes: master switches of inflammation". Cell Death Differ. 14 (1): 10–22. doi:10.1038/sj.cdd.4402038. PMID 16977329.

[6] Smith C, Soti S, Jones Torey A, Nakagawa A, Xue D, and Yin H (2017). "NSAIDs are Caspase Inhibitors". Cell Chem Biol. 24 (3): 281–292. doi:10.1016/j.chembiol.2017.02.003. PMC 5357154. PMID 28238723.

[1]

[2]

[3]

[4]

[5]

[6]

Proteases: cysteine proteases (EC 3.4.22)
Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14
Fruit-derived	Papain Ficain Bromelain Actinidain
Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2
Cathepsin	B C F H K L1/L2 O S W Z
Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain 3C-like protease Gingipain R Gingipain K

Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

See also

References

External links