Cas2

CRISPR-associated protein 2
Streptococcus pyogenes Cas2. PDB: 4QR2​
Identifiers
Symbolcas2
PfamPF09827
InterProIPR019199
Available protein structures:
PDB  IPR019199 PF09827 (ECOD; PDBsum)  
AlphaFold

Cas2 is a protein associated with CRISPR that is involved with spacer acquisition. Representative cas2 proteins have been characterized as endonucleases that cleave single-stranded RNAs preferentially within U-rich regions,[1] or as metal-dependent endonucleases targeting double-stranded (ds)DNA [2]

References

  1. ^ Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, et al. (July 2008). "A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats". The Journal of Biological Chemistry. 283 (29): 20361–71. doi:10.1074/jbc.M803225200. PMC 2459268. PMID 18482976.
  2. ^ Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A (October 2012). "Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein". The Journal of Biological Chemistry. 287 (43): 35943–52. doi:10.1074/jbc.M112.382598. PMC 3476262. PMID 22942283.
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