Carboxynorspermidine decarboxylase
| Carboxynorspermidine decarboxylase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 4.1.1.96 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Carboxynorspermidine decarboxylase (EC 4.1.1.96, carboxyspermidine decarboxylase, CANSDC, VC1623 (gene)) is an enzyme with systematic name carboxynorspermidine carboxy-lyase (bis(3-aminopropyl)amine-forming).[1][2][3] This enzyme catalyses two related decarboxylation reactions.
The enzyme contains pyridoxal 5'-phosphate.[4] It acts on biosynthetic intermediates which are produced by the enzyme carboxynorspermidine synthase and together these are the main way that bacteria which form the gut microbiota in humans make spermidine and norspermidine.[1][3]
References
- ^ a b Lee J, Sperandio V, Frantz DE, Longgood J, Camilli A, Phillips MA, Michael AJ (April 2009). "An alternative polyamine biosynthetic pathway is widespread in bacteria and essential for biofilm formation in Vibrio cholerae". The Journal of Biological Chemistry. 284 (15): 9899–907. doi:10.1074/jbc.M900110200. PMC 2665113. PMID 19196710.
- ^ Deng X, Lee J, Michael AJ, Tomchick DR, Goldsmith EJ, Phillips MA (August 2010). "Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine". The Journal of Biological Chemistry. 285 (33): 25708–19. doi:10.1074/jbc.M110.121137. PMC 2919134. PMID 20534592.
- ^ a b Hanfrey CC, Pearson BM, Hazeldine S, Lee J, Gaskin DJ, Woster PM, Phillips MA, Michael AJ (December 2011). "Alternative spermidine biosynthetic route is critical for growth of Campylobacter jejuni and is the dominant polyamine pathway in human gut microbiota". The Journal of Biological Chemistry. 286 (50): 43301–12. doi:10.1074/jbc.M111.307835. PMC 3234850. PMID 22025614.
- ^ Enzyme 4.1.1.96 at KEGG Pathway Database.
External links
- Carboxynorspermidine+decarboxylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)