BP holin family

The β-proteobacterial holin (BP-Hol) family (TC# 1.E.50) is a small family that includes members derived from a number of Burkholderia phage as well as a Poloromonas species. As of April 3, 2016, this family belongs to the Holin superfamily II. Members of Saier Bioinformatics Lab at University of California, San Diego found that the BP-Hol family is most closely related to the T7 holin family (TC# 1.E.6).[1] These proteins are of 60 to 110 amino acyl residues (aas) in length and exhibit 1 or 2 transmembrane segments (TMSs). Some are annotated as type II hollins and may be related to members of the T7 Holin family (TC# 1.E.6), although BP-Hol proteins remain functionally uncharacterized. A representative list of the proteins belonging to the BP-Hol family can be found in the Transporter Classification Database.[2]

See also

Further reading

  • "BcepMigl_gp72 - Holin - Burkholderia phage BcepMigl - BcepMigl_gp72 gene & protein".www.uniprot.org. Retrieved 2016-03-29.
  • Gründling, A; Manson, MD; Young, R (2001). "Holins kill without warning". Proc. Natl. Acad. Sci. U.S.A. 98: 9348–52. doi:10.1073/pnas.151247598. PMC 55423. PMID 11459934..
  • Preston, GM; Studholme, DJ; Caldelari, I (2005). "Profiling the secretomes of plant pathogenic Proteobacteria". FEMS Microbiol Rev. 29: 331–60. doi:10.1016/j.femsre.2004.12.004. PMID 15808747..
  • Reddy, BL; Saier, MH (2013). "Topological and phylogenetic analyses of bacterial holin families and superfamilies". Biochim. Biophys. Acta. 1828: 2654–71. doi:10.1016/j.bbamem.2013.07.004. PMC 3788059. PMID 23856191..
  • Saier, MH; Reddy, BL (2015). "Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications". J. Bacteriol. 197: 7–17. doi:10.1128/JB.02046-14. PMC 4288690. PMID 25157079..
  • Wang, IN; Smith, DL; Young, R (2000). "Holins: the protein clocks of bacteriophage infections". Annu. Rev. Microbiol. 54: 799–825. doi:10.1146/annurev.micro.54.1.799. PMID 11018145..

References

  1. ^ "Holin Superfamily II". TCDB. Retrieved 2016-04-04.
  2. ^ "1.E.50. The β-Proteobacterial Holin (BP-Hol) Family". TCDB. Retrieved 2016-03-29.

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