Astragaloside

Astragalosides are a series of related chemical compounds isolated from Astragalus membranaceus.[1]

Also known as astrasieversianin, AS-IV, astraversianin XIV, or cyclosiversioside F, it is a white powder with a melting point of 284 °C–285 °C (Wang et al., 1987). Its molecular formula is C41H68O14, and its theoretically accurate molecular weight is 784.4609.[2]

Research on astragaloside IV, TA-65 in particular, has found that it has the potential to activate the telomerase enzyme in humans to lengthen telomeres at the ends of human chromosomes.[3]

References

  1. ^ Ren, S; Zhang, H; Mu, Y; Sun, M; Liu, P (2013). "Pharmacological effects of Astragaloside IV: A literature review". Journal of Traditional Chinese Medicine. 33 (3): 413–6. doi:10.1016/S0254-6272(13)60189-2. PMID 24024343.
  2. ^ Xia, Dongqin; Li, Wenjie; Tang, Ce; Jiang, Juan (17 February 2023). "Astragaloside IV, as a potential anticancer agent". Frontiers in Pharmacology. 14. doi:10.3389/fphar.2023.1065505. ISSN 1663-9812. PMC 9981805. PMID 36874003. This article incorporates text from this source, which is available under the CC BY 4.0 license.
  3. ^ de Jaeger, Christophe; Kruiskamp, Saskia; Voronska, Elena; Lamberti, Carla; Baramki, Hani; Beaudeux, Jean Louis; Cherin, Patrick (2024-09-03). "A Natural Astragalus-Based Nutritional Supplement Lengthens Telomeres in a Middle-Aged Population: A Randomized, Double-Blind, Placebo-Controlled Study". Nutrients. 16 (17): 2963. doi:10.3390/nu16172963. ISSN 2072-6643. Archived from the original on 2026-01-14.
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