Astatobenzene
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| Preferred IUPAC name
phenylastatine | |
| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C6H5At | |
| Molar mass | 287 g·mol−1 |
| Related compounds | |
Related halobenzenes
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Fluorobenzene Chlorobenzene Bromobenzene Iodobenzene |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
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Astatobenzene is an organoastatine chemical compound with the formula C6H5At. This is a compound in which an astatine atom, the rarest halogen, is bonded to a benzene ring.[1]
Synthesis
Several methods of obtaining astatobenzene are described.[2][3][4]
Homogeneous exchange between iodobenzene and astatine iodide at room temperature:
- C6H5I + AtI → C6H5At + I2
Also, synthesis from phenylhydrazine and astatine iodide:
- C6H5NHNH2 + AtI + I2 → C6H5At + N2 + 3 HI
Also, thermal decomposition of diphenyliodonium iodide containing diphenyliodonium astatide:
- (C6H5)2IAt → C6H5At + C6H5I
Uses
The compound is of scientific interest primarily in research contexts involving astatine chemistry and radiopharmaceutical applications, where astatine radioactive isotopes are used.[5][6]
References
- ^ Hirata, Saki; Mishiro, Kenji; Washiyama, Kohshin; Munekane, Masayuki; Fuchigami, Takeshi; Arano, Yasushi; Takahashi, Kazuhiro; Kinuya, Seigo; Ogawa, Kazuma (23 January 2025). "In Vivo Stability Improvement of Astatobenzene Derivatives by Introducing Neighboring Substituents". Journal of Medicinal Chemistry. 68 (2): 1540–1552. doi:10.1021/acs.jmedchem.4c02188. ISSN 0022-2623. PMID 39757786. Retrieved 1 September 2025.
- ^ Samson, G.; Aten, A. H. W. (1 June 1970). "Syntheses of Astatobenzene". Radiochimica Acta. 13 (4): 220–221. doi:10.1524/ract.1970.13.4.220. ISSN 2193-3405. Retrieved 1 September 2025.
- ^ Advances in Inorganic Chemistry. Academic Press. 27 May 1987. p. 58. ISBN 978-0-08-057880-4. Retrieved 1 September 2025.
- ^ Kugler, Hans K.; Keller, Cornelius (9 March 2013). At Astatine. Springer Science & Business Media. p. 239. ISBN 978-3-662-05868-8. Retrieved 1 September 2025.
- ^ Vásaros, L.; Berei, K.; Norseyev, Yu V. (1 June 1989). "Some Replacement and Addition Reactions of Astatine". Radiochimica Acta. 47 (2–3): 119–128. doi:10.1524/ract.1989.47.23.119. ISSN 2193-3405. Retrieved 1 September 2025.
- ^ Hagen, A. P. (17 September 2009). Inorganic Reactions and Methods, The Formation of Bonds to Halogens (Part 1). John Wiley & Sons. p. 426. ISBN 978-0-470-14538-8. Retrieved 1 September 2025.