Anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
| Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.1 | ||||||||
| CAS no. | 9059-17-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Anthranilate 1,2-dioxygenase (deaminating, decarboxylating) (EC 1.14.12.1) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are anthranilic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are catechol, carbon dioxide, oxidised NAD+, and ammonia. The enzyme can also use nicotinamide adenine dinucleotide phosphate as a cofactor.[1][2]
This enzyme is an oxidoreductase which uses molecular oxygen as oxidant and incorporates its atoms into the product.[3] The systematic name of this enzyme class is anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating). Other names in common use include anthranilate hydroxylase, anthranilic hydroxylase, and anthranilic acid hydroxylase. It participates in three metabolic pathways: benzoate degradation via hydroxylation, carbazole degradation, and nitrogen metabolism. It requires ferrous iron.[1]
References
- ^ a b Enzyme 1.14.12.1 at KEGG Pathway Database.
- ^ Taniuchi H, Hatanaka M, Kuno S, Hayaishi O, Nakajima M, Kurihara N (1964). "Enzymatic formation of catechol from anthranilic acid". J. Biol. Chem. 239 (7): 2204–2211. doi:10.1016/S0021-9258(20)82221-2. PMID 14209949.
- ^ Kobayashi S, Hayaishi O (1970). "Anthranilic acid conversion to catechol (Pseudomonas)". Metabolism of Amino Acids and Amines Part A. Methods Enzymol. Vol. 17A. pp. 505–510. doi:10.1016/0076-6879(71)17231-x. ISBN 978-0-12-181874-6.