Aminomethylsulfonic acid

Aminomethylsulfonic acid
Names
	IUPAC name Aminomethanesulfonic acid
	Other names Aminomethylenesulfonic acid
Identifiers
CAS Number	13881-91-9;
3D model (JSmol)	Interactive image;
ChEMBL	ChEMBL1741886;
ChemSpider	75612;
ECHA InfoCard	100.034.212
EC Number	237-649-6;
PubChem CID	83791;
UNII	OLA224Z482;
CompTox Dashboard (EPA)	DTXSID2065670 ;
	InChI InChI=1S/CH5NO3S/c2-1-6(3,4)5/h1-2H2,(H,3,4,5) Key: OBESRABRARNZJB-UHFFFAOYSA-N;
	SMILES C(N)S(=O)(=O)O;
Properties
Chemical formula	CH5NO3S
Molar mass	111.12 g·mol−1
Appearance	White crystalline solid
Melting point	190–194 °C (374–381 °F; 463–467 K)
Hazards
	GHS labelling:[1]
Pictograms
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260, P264, P280, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P363, P405, P501
Related compounds
Related compounds	Taurine; Sulfamic acid; Methanesulfonic acid;
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Aminomethylsulfonic acid (also called aminomethylenesulfonic acid and aminomethanesulfonic acid) is an organic chemical compound, with amino (−NH₂) and sulfonic acid (−SO₂−OH) groups on the carbon atom. Its chemical formula is N H₂CH₂S O₂OH, and it has a molar mass of 111.12 g/mol.

Synthesis

Aminomethane sulfonic acid can be made by the reaction between hexamethylenetetramine (hexamine) with sulfur dioxide (SO₂) in an aqueous environment.^[2]

Properties

Aminomethanesulfonic acid is a corrosive solid. It could be thought of as the sulfonic acid analogue of glycine, just like aminomethylphosphonic acid is the phosphonic analogue of glycine.^[3] Its density is ~1.7 g/cm³.^[4]

Aminomethanesulfonic acid appears as a white crystalline solid that dissolves readily in water. It exhibits amphoteric behavior, meaning it can act as either an acid or a base depending on the conditions. Heating the compound above 280 °C leads to decomposition, releasing sulfur dioxide and other gaseous products.^[5]

Uses

Although aminomethanesulfonic acid has limited commercial use, it has been employed in research as a reagent and as a buffering agent. It has also been studied as a structural analog of taurine in biochemical research, helping to investigate metabolic pathways and sulfonic acid derivatives.^[6]

Dangers

Aminomethanesulfonic acid can cause skin and eye burns, it is an dermatotoxin.

References

^ "Aminomethanesulfonic acid (CAS RN: 13881-91-9)". CAS Common Chemistry. Chemical Abstracts Service. Retrieved 2026-01-15.
^ Khoma, R. E.; et al. (2019). "Synthesis, crystal structure, and spectral characteristics of N-(n-propyl) aminomethanesulfonic acid. Acute toxicity of aminomethanesulfonic acid and its N-alkylated derivatives". Voprosy Khimii i Khimicheskoi Tekhnologii. 6 (6): 255–262. doi:10.32434/0321-4095-2019-127-6-255-262.
^ CID 83791 from PubChem
^ CSID:75612, https://www.chemspider.com/Chemical-Structure.75612.html, (accessed 16:39, Jan 15, 2026)
^ Becker, K. (1974). "Thermal decomposition of aminomethanesulfonic acid and related sulfonic acids". Journal of Thermal Analysis. 7 (3): 311–318. doi:10.1007/BF01911590.
^ Huxtable, R. (1982). "Taurine analogs and metabolic studies". Advances in Experimental Medicine and Biology. 141: 261–273. doi:10.1007/978-1-4684-8181-5_23.

[1] "Aminomethanesulfonic acid (CAS RN: 13881-91-9)". CAS Common Chemistry. Chemical Abstracts Service. Retrieved 2026-01-15.

[2] Khoma, R. E.; et al. (2019). "Synthesis, crystal structure, and spectral characteristics of N-(n-propyl) aminomethanesulfonic acid. Acute toxicity of aminomethanesulfonic acid and its N-alkylated derivatives". Voprosy Khimii i Khimicheskoi Tekhnologii. 6 (6): 255–262. doi:10.32434/0321-4095-2019-127-6-255-262.

[3] CID 83791 from PubChem

[4] CSID:75612, https://www.chemspider.com/Chemical-Structure.75612.html, (accessed 16:39, Jan 15, 2026)

[5] Becker, K. (1974). "Thermal decomposition of aminomethanesulfonic acid and related sulfonic acids". Journal of Thermal Analysis. 7 (3): 311–318. doi:10.1007/BF01911590.

[6] Huxtable, R. (1982). "Taurine analogs and metabolic studies". Advances in Experimental Medicine and Biology. 141: 261–273. doi:10.1007/978-1-4684-8181-5_23.

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