AP503

AP503
Identifiers
	IUPAC name methyl 3-[[2-(2,4-dimethylphenoxy)acetyl]amino]-4-(4-ethylpiperazin-1-yl)benzoate;
CAS Number	767299-99-0;
PubChem CID	7346086;
ChemSpider	5673228;
Chemical and physical data
Formula	C24H31N3O4
Molar mass	425.529 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCN1CCN(CC1)C2=C(C=C(C=C2)C(=O)OC)NC(=O)COC3=C(C=C(C=C3)C)C;
	InChI InChI=1S/C24H31N3O4/c1-5-26-10-12-27(13-11-26)21-8-7-19(24(29)30-4)15-20(21)25-23(28)16-31-22-9-6-17(2)14-18(22)3/h6-9,14-15H,5,10-13,16H2,1-4H3,(H,25,28); Key:CPGGKKARFZXWMR-UHFFFAOYSA-N;

AP503 is a chemical compound which acts as an agonist at the androgen receptor GPR133. It increases muscle growth and bone density in animal models, and may have potential applications in the treatment of osteoporosis and sarcopenia in the elderly.^[1]^[2]

References

^ Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, et al. (March 2025). "Identification, structure, and agonist design of an androgen membrane receptor". Cell. 188 (6): 1589–1604.e24. doi:10.1016/j.cell.2025.01.006. PMID 39884271.
^ Lehmann J, Lin H, Zhang Z, Wiermann M, Ricken AM, Brinkmann F, et al. (June 2025). "The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation". Signal Transduction and Targeted Therapy. 10 (1) 199. doi:10.1038/s41392-025-02291-y. PMC 12206920. PMID 40583059.

[1] Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, et al. (March 2025). "Identification, structure, and agonist design of an androgen membrane receptor". Cell. 188 (6): 1589–1604.e24. doi:10.1016/j.cell.2025.01.006. PMID 39884271.

[2] Lehmann J, Lin H, Zhang Z, Wiermann M, Ricken AM, Brinkmann F, et al. (June 2025). "The mechanosensitive adhesion G protein-coupled receptor 133 (GPR133/ADGRD1) enhances bone formation". Signal Transduction and Targeted Therapy. 10 (1) 199. doi:10.1038/s41392-025-02291-y. PMC 12206920. PMID 40583059.

[1]

[2]

See also

References