4-hydroxyphenylacetate 1-monooxygenase
| 4-hydroxyphenylacetate 1-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.18 | ||||||||
| CAS no. | 55326-44-8 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
4-hydroxyphenylacetate 1-monooxygenase (EC 1.14.13.18) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are 4-hydroxyphenylacetic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen and a proton. Its products are homogentisic acid, oxidised NAD+, and water. The enzyme can use nicotinamide adenine dinucleotide phosphate as an alternative cofactor.[1][2]
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating). Other names in common use include 4-hydroxyphenylacetate 1-hydroxylase, 4-hydroxyphenylacetic 1-hydroxylase, and 4-HPA 1-hydroxylase. This enzyme participates in tyrosine metabolism.[1]
References
- ^ a b Enzyme 1.14.13.18 at KEGG Pathway Database.
- ^ Hareland, W. A.; Crawford, R. L.; Chapman, P. J.; Dagley, S. (1975). "Metabolic function and properties of 4-hydroxyphenylacetic acid 1-hydroxylase from Pseudomonas acidovorans". Journal of Bacteriology. 121 (1): 272–285. doi:10.1128/jb.121.1.272-285.1975. PMC 285641. PMID 234937.