4-hydroxymuconic-semialdehyde dehydrogenase
| 4-hydroxymuconic-semialdehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.2.1.61 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a 4-hydroxymuconic-semialdehyde dehydrogenase (EC 1.2.1.61) is an enzyme that catalyzes the chemical reaction
The three substrates of this enzyme are 4-hydroxymuconic semialdehyde, oxidised nicotinamide adenine dinucleotide (NAD+), and water. Its products are maleylacetic acid, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase. This enzyme participates in gamma-hexachlorocyclohexane degradation.
References
- ^ Enzyme 1.2.1.61 at KEGG Pathway Database.
- ^ Spain JC, Gibson DT (1991). "Pathway for Biodegradation of p-Nitrophenol in a Moraxella sp". Appl. Environ. Microbiol. 57 (3): 812–819. Bibcode:1991ApEnM..57..812S. doi:10.1128/aem.57.3.812-819.1991. PMC 182799. PMID 16348446.