3-phenylpropanoate dioxygenase
| 3-phenylpropanoate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.19 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-phenylpropanoate dioxygenase (EC 1.14.12.19) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are phenylpropanoic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen, and a proton. Its products are the cis-diol, 3-[(5S,6R)-5,6-dihydroxycyclohexa-1,3-dienyl]propanoic acid, and oxidised NAD+.[1][2][3]
This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of this enzyme class is 3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating). Other names in common use include HcaA1A2CD, Hca dioxygenase, and 3-phenylpropionate dioxygenase. It can catalyse the same reaction in related compounds, for example cinnamic acid.[1]
References
- ^ a b Enzyme 1.14.12.19 at KEGG Pathway Database.
- ^ Diaz E, Ferrandez A, Garcia JL (1998). "Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12". J. Bacteriol. 180 (11): 2915–23. doi:10.1128/JB.180.11.2915-2923.1998. PMC 107259. PMID 9603882.
- ^ Burlingame R, Chapman PJ (1983). "Catabolism of phenylpropionic acid and its 3-hydroxy derivative by Escherichia coli". J. Bacteriol. 155 (1): 113–21. doi:10.1128/jb.155.1.113-121.1983. PMC 217659. PMID 6345502.