3-hydroxybenzoate 6-monooxygenase
| 3-hydroxybenzoate 6-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.24 | ||||||||
| CAS no. | 51570-26-4 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
3-hydroxybenzoate 6-monooxygenase (EC 1.14.13.24) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are 3-hydroxybenzoic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen and a proton. Its products are gentisic acid, oxidised NAD+, and water.[1][2]
The enzyme is a flavin-containing monooxygenase that uses molecular oxygen as oxidant and incorporates one of its atoms into the starting material. The systematic name of this enzyme class is 3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating). Other names in common use include 3-hydroxybenzoate 6-hydroxylase, m-hydroxybenzoate 6-hydroxylase, and 3-hydroxybenzoic acid-6-hydroxylase. It participates in benzoate degradation via hydroxylation and uses flavin adenine dinucleotide as a cofactor.[1]
References
- ^ a b Enzyme 1.14.13.24 at KEGG Pathway Database.
- ^ Groseclose EE, Ribbons DW, Hughes H (1973). "3-Hydroxybenzoate 6-hydroxylase from Pseudomonas aeruginosa". Biochem. Biophys. Res. Commun. 55 (3): 897–903. Bibcode:1973BBRC...55..897G. doi:10.1016/0006-291X(73)91228-X. PMID 4357436.