3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase
| 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.116 | ||||||||
| CAS no. | 132084-81-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase (EC 2.1.1.116) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (S)-3'-hydroxy-N-methylcoclaurine and S-adenosyl methionine (SAM). Its products are (S)-reticuline and S-adenosylhomocysteine (SAH).[1][2]
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase. This enzyme participates in alkaloid biosynthesis.[3]
References
- ^ Enzyme 2.1.1.116 at KEGG Pathway Database.
- ^ Frenzel T, Zenk MH (1990). "S-Adenosyl-L-methionine: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase, a regio- and stereoselective enzyme of the (S)-reticuline pathway". Phytochemistry. 29 (11): 3505–3511. doi:10.1016/0031-9422(90)85265-H.
- ^ Tian Y, Kong L, Li Q, Wang Y, Wang Y, An Z, Ma Y, Tian L, Duan B, Sun W, Gao R, Chen S, Xu Z (November 2024). "Structural diversity, evolutionary origin, and metabolic engineering of plant specialized benzylisoquinoline alkaloids". Natural Product Reports. 41 (11): 1787–1810. doi:10.1039/d4np00029c. PMID 39360417.