2-chlorobenzoate 1,2-dioxygenase
| 2-chlorobenzoate 1,2-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.12.13 | ||||||||
| CAS no. | 125268-83-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2-chlorobenzoate 1,2-dioxygenase (EC 1.14.12.13) is an enzyme from the bacterium Burkholderia cepacia that catalyzes the chemical reaction
The four substrates of this enzyme are 2-chlorobenzoic acid, reduced nicotinamide adenine dinucleotide (NADH), oxygen and a proton. Its products are catechol, carbon dioxide, oxidised NAD+, and a chloride ion.[1][2]
This enzyme is an oxidoreductase that uses molecular oxygen as oxidant and incorporates both its atoms into the starting material. The systematic name of its class is 2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating). This enzyme is also called 2-halobenzoate 1,2-dioxygenase. It can oxidise other 2-halo substituted benzoic acids.[1]
References
- ^ a b Enzyme 1.14.12.13 at KEGG Pathway Database.
- ^ Fetzner S, Muller R, Lingens F (1989). "Degradation of 2-chlorobenzoate by Pseudomonas cepacia 2CBS". Biol. Chem. Hoppe-Seyler. 370 (11): 1173–82. doi:10.1515/bchm3.1989.370.2.1173. PMID 2610934.