2,5-dihydroxypyridine 5,6-dioxygenase
| 2,5-dihydroxypyridine 5,6-dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.13.11.9 | ||||||||
| CAS no. | 9029-57-6 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
2,5-dihydroxypyridine 5,6-dioxygenase (EC 1.13.11.9) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are 2,5-dihydroxypyridine and oxygen. Its product is N-formylmaleamic acid.[1][2][3][4][5]
This enzyme belongs to the family of oxidoreductases, specifically those acting on single donors with O2 as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O2. It employs one cofactor, iron.
This enzyme participates in nicotinate and nicotinamide metabolism.[6]
Nomenclature
The systematic name of this enzyme class is 2,5-dihydroxypyridine:oxygen 5,6-oxidoreductase. Other names in common use include 2,5-dihydroxypyridine oxygenase, and pyridine-2,5-diol dioxygenase.
References
- ^ Enzyme 1.13.11.9 at KEGG Pathway Database.
- ^ Behrman, E.J.; Stanier, R.Y. (1957). "The Bacterial Oxidation of Nicotinic Acid". Journal of Biological Chemistry. 228 (2): 923–945. doi:10.1016/S0021-9258(18)70671-6. PMID 13475371.
- ^ Gauthier, Joseph J.; Rittenberg, Sydney C. (1971). "The Metabolism of Nicotinic Acid". Journal of Biological Chemistry. 246 (11): 3737–3742. doi:10.1016/S0021-9258(18)62189-1.
- ^ Gauthier, Joseph J.; Rittenberg, Sydney C. (1971). "The Metabolism of Nicotinic Acid". Journal of Biological Chemistry. 246 (11): 3743–3748. doi:10.1016/S0021-9258(18)62190-8.
- ^ Behrman, E. J. (2008). "N -Formylmaleamic acid: An intermediate in nicotinic acid metabolism". Proceedings of the National Academy of Sciences. 105 (47): E88, author reply E89. doi:10.1073/pnas.0808695105. PMC 2587544. PMID 19020104.
- ^ Henke, Matthew T.; Snider, Mark J. (1 April 2011). "Mechanistic studies of 2,5-dihydroxypyridine 5,6-dioxygenase (NicX) from Bordetella bronchiseptica". The FASEB Journal. 25 (1 Supplement): 714.2. doi:10.1096/fasebj.25.1_supplement.714.2 (inactive 28 February 2026). ISSN 0892-6638.
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