(S)-2-hydroxy-fatty-acid dehydrogenase
| (S)-2-hydroxy-fatty-acid dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.1.1.99 | ||||||||
| CAS no. | 37250-33-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, (S)-2-hydroxy-fatty-acid dehydrogenase (EC 1.1.1.99) is an enzyme that catalyzes the chemical reaction
The two substrates of this enzyme are (S)-2-hydroxystearic acid and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 2-oxostearic acid, reduced NADH, and a proton.[1][2]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-2-hydroxystearate:NAD+ oxidoreductase. Other names in common use include dehydrogenase, L-2-hydroxy fatty acid, L-2-hydroxy fatty acid dehydrogenase, and 2-hydroxy fatty acid oxidase.
See also
- (R)-2-hydroxy-fatty-acid dehydrogenase which acts on the enantiomer of the hydroxy acid.
References
- ^ Enzyme 1.1.1.99 at KEGG Pathway Database.
- ^ Huang WY, Tang J (1970). "Carboxyl-terminal sequence of human gastricsin and pepsin". J. Biol. Chem. 245 (9): 2189–93. doi:10.1016/S0021-9258(18)63137-0. PMID 4909888.