(−)-menthol monooxygenase
| (−)-menthol monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.13.46 | ||||||||
| CAS no. | 117590-75-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
(−)-menthol monooxygenase (EC 1.14.13.46) is an enzyme that catalyzes the chemical reaction
The four substrates of this enzyme are (−)-menthol, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are p-menthane-3,8-diol, oxidised NADP+, and water.[1][2]
This enzyme is an oxidoreductase, acting on paired donors, with molecular oxygen as oxidant and incorporating one of its atoms. The systematic name of this enzyme class is (−)-menthol,NADPH:oxygen oxidoreductase (8-hydroxylating). This enzyme is also called l-menthol monooxygenase.
Uses
Use of (−)-menthol monooxygenase has been explored by several companies including Procter & Gamble for cleaning products.[3][4][5]
References
- ^ Enzyme 1.14.13.46 at KEGG Pathway Database.
- ^ Madyastha KM, Srivatsan V (1988). "Studies on the metabolism of l-menthol in rats". Drug Metab. Dispos. 16 (5): 765–72. doi:10.1016/S0090-9556(25)07052-7. PMID 2906604.
- ^ "Cleaning compositions comprising a specific oxygenase"|Alfons, Ivan Maurice et al.|https://patents.google.com/patent/EP1002040B2/en
- ^ "Methods for conducting assays for enzyme activity on protein microarrays"|Zhou, Fang X.; Schweitzer, Barry| https://patents.google.com/patent/US7635572B2/en?oq=US7635572B2
- ^ "Cleaning compositions contain a specific oxygenase"|Barnabas, Mary et al.|https://patents.google.com/patent/DE69727704T3/en